ArticleJournal of drug delivery science and technology2021
Effect of pH Modifiers on the Solubility, Dissolution Rate, and Stability of Telmisartan Solid Dispersions Produced by Hot-melt Extrusion Technology.
Article in Journal of drug delivery science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Tailored Drug Release with Improved Solubility via Spray Drying and Functional Ready-to-Fill Capsules.Pharmaceutics · 2026Article
- Hot-melt extruded ibuprofen ternary solid dispersions using in-line UV-Vis: Impact of an ionizable polymer on thermodynamics and dissolution.International journal of pharmaceutics: X · 2026Article
- Soybean Polysaccharides Increase the Stability of Lansoprazole Enteric Coated Pellets.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Recent Techniques to Improve Amorphous Dispersion Performance with Quality Design, Physicochemical Monitoring, Molecular Simulation, and Machine Learning.Pharmaceutics · 2025Review
- Review
- Combining High-Throughput Screening and Machine Learning to Predict the Formation of Both Binary and Ternary Amorphous Solid Dispersion Formulations for Early Drug Discovery and Development.Pharmaceutical research · 2025Article
- Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-Pharmaceutics · 2025Article
- Investigating Strategies to Enhance the Aqueous Solubility of Ketamine HCl for Intranasal Delivery.Pharmaceutics · 2024Article
- Enabling a novel solvent method on Albendazole solid dispersion to improve the in vivo bioavailability.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2024Article
- Disulfiram 3D printed film produced via hot-melt extrusion techniques as a potential anticervical cancer candidate.International journal of pharmaceutics · 2023Article
- Investigation of hot melt extrusion process parameters on solubility and tabletability of atorvastatin calcium in presence of NeusilinJournal of drug delivery science and technology · 2023Article
- Article
- Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization.Pharmaceutics · 2022Review
- Preparation of Curcumin-EudragitMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The aim of the current study was to investigate the dual effect of an amorphous solid dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility and stability of telmisartan. Hydroxypropyl methylcellulose acetate succinate L grade was used as a polymeric carrier and recrystallization inhibitor, and meglumine, sodium carbonate, or Neusilin S2 were incorporated as pH modifiers to generate a desirable microenvironmental pH in the solid dispersions. Differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy were incorporated to obtain the solid-state characterizations of telmisartan, and the results confirm a partial transformation of telmisartan to an amorphous state. An
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.