ArticleFrontiers in immunology2021
Tissue-Resident-Memory CD8
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Tissue-Resident and Effector-Memory Lymphocyte Recruitment to the Ocular Mucosa Requires CCL28/CCR10 Signaling During Recurrent HSV-1 Infection.bioRxiv : the preprint server for biology · 2026Article
- Epithelial interferon-γ responsiveness shapes chemokine induction and clinical outcomes in herpes simplex virus infection.PLoS pathogens · 2026Article
- Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes.Inflammation and regeneration · 2026Review
- Host Immune Response Mechanisms Against Herpes Simplex Virus Type 2 Infection.Pathogens (Basel, Switzerland) · 2026Review
- Direct comparison of three herpes simplex virus-2 vaccine candidates using peripheral or mucosal routes of vaccination.Vaccine · 2026Article
- Enumeration, Phenotyping, and Clinical Associations of Tissue-Resident T Cells in the Ecto- and Endocervix of Women Attending a Colposcopy Clinic.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Regulatory T cells restrain IL-15-mediated cytotoxic and bystander T cell activity in mucosal tissue without compromising antigen-driven memory.bioRxiv : the preprint server for biology · 2026Article
- Genital herpes shedding episodes associate with altered spatial organization and activation of mucosal immune cells.JCI insight · 2026Article
- Article
- Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin.bioRxiv : the preprint server for biology · 2025Article
- Design and immunogenicity of a quadrivalent mRNA vaccine targeting HSV-2 with comparative evaluation of co-formulated and admixed formulations.Frontiers in immunology · 2025Article
- Evaluation of oral herpes simplex virus shedding among solid organ transplant recipients: A pilot study.Transplant infectious disease : an official journal of the Transplantation Society · 2024Article
- Local Power: The Role of Tissue-Resident Immunity in Human Genital Herpes Simplex Virus Reactivation.Viruses · 2024Review
- Optimizing deep learning-based segmentation of densely packed cells using cell surface markers.BMC medical informatics and decision making · 2024Article
- Therapeutic vaccines for herpesviruses.The Journal of clinical investigation · 2024Review
- Summary of the Centers for Disease Control and Prevention/National Institute of Allergy and Infectious Diseases Joint Workshop on Genital Herpes: 3-4 November 2022.Open forum infectious diseases · 2024Review
- QnAs with David M. Knipe.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Nuclear interferon-stimulated gene product maintains heterochromatin on the herpes simplex viral genome to limit lytic infection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Optimizing Deep Learning-Based Segmentation of Densely Packed Cells using Cell Surface Markers.Research square · 2023Article
- Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands.The Journal of investigative dermatology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 1 country.
Tao PengDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Khamsone PhasoukVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Catherine N SodroskiDepartment of Microbiology and Virology Program, Blavatnik Institute, Harvard Medical School, Boston, MA, United States.
Sijie SunDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Yon HwangboDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Erik D LaytonDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Lei JinVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Alexis KlockDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Kurt DiemDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Amalia S MagaretDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Lichen JingDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Kerry LaingDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Alvason LiDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Meei-Li HuangVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Max MertensDepartment of Microbiology and Virology Program, Blavatnik Institute, Harvard Medical School, Boston, MA, United States.
Christine JohnstonDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Keith R JeromeDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
David M KoelleDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Anna WaldDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
David M KnipeDepartment of Microbiology and Virology Program, Blavatnik Institute, Harvard Medical School, Boston, MA, United States.
Lawrence CoreyDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Jia ZhuDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
University of Washington · USFred Hutch Cancer Center · USHarvard University · USBenaroya Research InstituteBoston VA Research Institute · US
Funding
THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 1991 to 2017
$34.3MLarge Scale T Cell Epitope Discovery: Local and Systemic T cell Response to Herpes Simplex Virus75N93019C00063 · NIAID · UNIVERSITY OF WASHINGTON · PI MYER, TIM · 2019 to 2023
$5.5MGenetics of Herpesvirus TransformationR01AI063106 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KNIPE, DAVID M. · 2004 to 2013
$3.8MCytotoxic T-Cell Responses to HSV: HIV-Infected PersonsR37AI042528 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE · 2002 to 2011
$3.5MHarnessing Tissue Resident Memory T Cells for Immunotherapy of Herpes Virus InfectionsR01AI134878 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE · 2018 to 2022
$3.4MModeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusionR01AI143773 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2024
$2.7MCYTOTOXIC T CELL RESPONSES TO HSV IN HIV INFECTIONR01AI042528 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE, ZHU, JIA · 1998 to 2016
$2.7MMechanisms of Protective Local Immunity in Human Female Reproductive TractR01AI111780 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2014 to 2018
$1.7MIncorporation of a histone variant into viral chromatin to promote herpes simplex virus replicationF31AI145062 · NIAID · HARVARD MEDICAL SCHOOL · PI SODROSKI, CATHERINE · 2019 to 2022
$105kThe Role of the Nuclear Envelope in Antiviral Signaling and HSV-1 RestrictionF31AI129207 · NIAID · HARVARD MEDICAL SCHOOL · PI MERTENS, MAX ELDON · 2017 to 2019
$102kNIAID NIH HHS 75N93019C00063NIAID NIH HHS F31 AI129207NIAID NIH HHS F31 AI145062NIAID NIH HHS P01 AI030731NIAID NIH HHS R01 AI042528NIAID NIH HHS R01 AI063106NIAID NIH HHS R01 AI111780NIAID NIH HHS R01 AI134878NIAID NIH HHS R01 AI143773NIAID NIH HHS R37 AI042528
Abstract
Tissue-resident-memory T cells (TRM) populate the body's barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete in a naturally recurring human disease. Using laser capture microdissection and transcriptional profiling, we investigate the impact of CD8TRM on the tissue microenvironment in skin biopsies sequentially obtained from a clinical cohort of diverse disease expression during herpes simplex virus 2 (HSV-2) reactivation. Epithelial cells neighboring CD8TRM display elevated and widespread innate and cell-intrinsic antiviral signature expression, largely related to IFNG expression. Detailed evaluation
Indexed as
Immunity, InnateImmunologic MemoryAdaptive ImmunityAdultAgedAntigens, ViralCD8-Positive T-LymphocytesCells, CulturedEpithelial CellsFemaleGene Expression ProfilingHerpes GenitalisHerpesvirus 2, HumanHost-Pathogen InteractionsHumansInterferon-gammaAntigens, ViralIFNG protein, humanInterferon-gammacell-intrinsic immunityhuman genital herpesIFI16 restriction factorinnate antiviral responsetissue microenvironmenttissue-resident-memory T cells (TRM)
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.