Evidence map›Paper›PMID 34552581›Full record

ArticleFrontiers in immunology2021

PD-L1-Mediated Immunosuppression in Oral Squamous Cell Carcinoma: Relationship With Macrophage Infiltration and Epithelial to Mesenchymal Transition Markers.

Tiantian Wu, Caijin Tang, Renchuan Tao, Xiangzhi Yong, Qiaozhi Jiang, Cong Feng

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  17. Effects of macrophages in OSCC progression.Frontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tiantian WuDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Caijin TangDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Renchuan TaoDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Xiangzhi YongDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Qiaozhi JiangDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Cong FengDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Guangxi Center for Disease Prevention and Control · CNGuangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, immune check-point inhibitors (ICIs), particularly inhibitors of programmed cell death-1 (PD-1) and PD ligand-1 (PD-L1) have become prominent in cancer treatment and also improved life expectancy of cancer patients. As key regulators of PD-1/PD-L1 axis, the recruitment of tumor-associated macrophages (TAMs) enhances aggressive and invasive properties of tumors in immunosuppressive tumor microenvironment (TME) and promotes epithelial-mesenchymal transition (EMT). The aims of the study were first to characterize the critical links among PD-L1, TME and EMT process and, further, to explore the sensitivity of different chemical agents to different PD-L1 expression groups. Bioinformatical analysis revealed that PD-L1 was highly expressed in OSCC and higher PD-L1 expression correlated with worse survival in patients. Notably, PD-L1 was positively correlated with macrophages infiltration and EMT markers gene expression. Moreover, patients in the PD-L1

Indexed as

Epithelial-Mesenchymal TransitionTumor MicroenvironmentAntineoplastic Combined Chemotherapy ProtocolsB7-H1 AntigenCell Line, TumorChemokinesDatabases, GeneticHumansImmune Checkpoint InhibitorsMouth NeoplasmsSignal TransductionSquamous Cell Carcinoma of Head and NeckTreatment OutcomeTumor-Associated MacrophagesB7-H1 AntigenCD274 protein, humanChemokinesImmune Checkpoint Inhibitorschemical drugsepithelial-mesenchymal transitionimmunosuppressive tumor microenvironmentmacrophagesPD-L1

Identifiers

PMID34552581
PMCPMC8450501
OpenAlexW3197555952

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.