ReviewFrontiers in physiology2021
Fatigue in Aviation: Safety Risks, Preventive Strategies and Pharmacological Interventions.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Impact of fatigue in surgeons on performance and patient outcome: systematic review.The British journal of surgery · 2024Pooled it
- Organizational Risk Factors for Aircrew Health: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2023Pooled it
- The Prevalence of Cardiometabolic Health Risk Factors among Airline Pilots: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Alcohol, Cancer, Neurobiology, and Aviation Safety: Implications for Aerospace Medicine and Pilot Health.Cureus · 2026Review
- Defining a Clinically Meaningful Within-Person Change Threshold for the Psychomotor Vigilance Test in Narcolepsy Type 1.Therapeutic innovation & regulatory science · 2026Article
- Beyond attention: methylphenidate reduces dishonesty in healthy adults.Psychopharmacology · 2026Article
- Observational
- Multimodal workload assessment during simulator-based instrument flight training.Frontiers in psychology · 2026Article
- From G tolerance to physiological state monitoring: mechanisms and adaptive protection.Frontiers in physiology · 2026Review
- To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals.Frontiers in human neuroscience · 2026Article
- Health Implications of Shift Work in Airline Pilots and Cabin Crew: A Narrative Review and Pilot Study Findings.Nutrients · 2025Review
- Occupational health in aviation: a cross-sectional study of barodontalgia among Malaysian air force pilots.BMC oral health · 2025Article
- ASFT-Transformer: A Fast and Accurate Framework for EEG-Based Pilot Fatigue Recognition.Sensors (Basel, Switzerland) · 2025Article
- Review
- Barriers and Facilitators to Mental Health Support Among Airline Pilots: A Narrative Review.Cureus · 2025Review
- The Flush Model: A Novel Framework to Manage Surgeons' Mental Fatigue and Cognitive Load.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- Prevalence of periodontitis and associated factors among Portuguese Air Force pilot cadets: a cross-sectional study.Frontiers in public health · 2025Article
- Assessment of flight fatigue using heart rate variability and machine learning approaches.Frontiers in neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue poses an important safety risk to civil and military aviation. In addition to decreasing performance in-flight (chronic) fatigue has negative long-term health effects. Possible causes of fatigue include sleep loss, extended time awake, circadian phase irregularities and work load. Despite regulations limiting flight time and enabling optimal rostering, fatigue cannot be prevented completely. Especially in military operations, where limits may be extended due to operational necessities, it is impossible to rely solely on regulations to prevent fatigue. Fatigue management, consisting of preventive strategies and operational countermeasures, such as pre-flight naps and pharmaceuticals that either promote adequate sleep (hypnotics or chronobiotics) or enhance performance (stimulants), may be required to mitigate fatigue in challenging (military) aviation operations. This review describes the pathophysiology, epidemiology and effects of fatigue and its impact on aviation, as well as several aspects of fatigue management and recommendations for future research in this field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.