Evidence map›Paper›PMID 34552476›Full record

ArticleFrontiers in human neuroscience2021

The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies.

Witney Chen, Lowry Kirkby, Miro Kotzev, Patrick Song, Ro'ee Gilron, Brian Pepin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Witney ChenRune Labs, San Francisco, CA, United States.
Lowry KirkbyRune Labs, San Francisco, CA, United States.
Miro KotzevRune Labs, San Francisco, CA, United States.
Patrick SongRune Labs, San Francisco, CA, United States.
Ro'ee GilronDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Brian PepinRune Labs, San Francisco, CA, United States.
Neurological Surgery · US

Funding

Data Archive for the Brain Initiative (DABI)R24MH114796 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, POURATIAN, NADER · 2018 to 2023
$6.2M
NIMH NIH HHS R24 MH114796
6 · The paper itself

Abstract

Advances in neuromodulation technologies hold the promise of treating a patient's unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients' symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies.

Indexed as

big datadata infrastructuredeep brain stimulationneuromodulationprecision medicine

Identifiers

PMID34552476
PMCPMC8450349
OpenAlexW3197132943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.