Evidence map›Paper›PMID 34552387›Full record

ReviewMediators of inflammation2021

Follicular Helper CD4

Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

Open access · goldAbstract readReview
In one paragraph

Review in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Immune-Related Gene Variants as Modifiers of Multiple Sclerosis Severity.International journal of molecular sciences · 2026
    Article
  2. Low-dose IL-2 Ameliorates Experimental Autoimmune Myasthenia Gravis in Rats by Restoring the CD4-positive Helper T-cell Balance Via the JAK/STAT5 Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Role of CD4Clinical and experimental medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  14. Article
  15. Article
  16. Low absolute CD4Annals of translational medicine · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xue ZhangDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.
Ruli GeDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.
Hongliang ChenDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.
Maxwell AhiaforSchool of International Studies, Binzhou Medical University, Yantai, 264003 Shandong, China.
Bin LiuInstitute for Metabolic & Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.
Jinbo ChenDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.ORCID https://orcid.org/0000-0001-5637-0922
Xueli FanDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, 256603 Shandong, China.ORCID https://orcid.org/0000-0002-7787-3702
Binzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular helper CD4

Indexed as

AnimalsCell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalHumansInducible T-Cell Co-Stimulator ProteinMultiple SclerosisT Follicular Helper CellsT-Lymphocytes, RegulatoryInducible T-Cell Co-Stimulator Protein

Identifiers

PMID34552387
PMCPMC8452443
OpenAlexW3201222750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.