Evidence map›Paper›PMID 34552346›Full record

ArticleJournal of inflammation research2021

Inflammation and Insulin Resistance in a Group of Sub-Saharan African Women with Polycystic Ovary Syndrome.

Christelle Chemaga Nkonpawa, Vicky Jocelyne Ama Moor, Aurel T Tankeu, Audrey Synthia Momo, Guy Sadeu Wafeu, Falmata Amazia, Jan Rene Nkeck, Tasha Manases, Julius Dohbit Sama, Simeon Pierre Choukem

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Christelle Chemaga NkonpawaDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.ORCID 0000-0002-9180-6987
Vicky Jocelyne Ama MoorDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Aurel T TankeuDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Audrey Synthia MomoDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Guy Sadeu WafeuCentre for Research on Filariasis and Other Tropical Diseases, Yaoundé, Cameroon.
Falmata AmaziaLaboratory of Biochemistry, University Teaching Hospital, Yaoundé, Cameroon.
Jan Rene NkeckLaboratory of Biochemistry, University Teaching Hospital, Yaoundé, Cameroon.ORCID 0000-0002-4353-2352
Tasha ManasesHealth and Human Development Research Network, Douala, Cameroon.
Julius Dohbit SamaDepartment of Obstetrics and Gynecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Simeon Pierre ChoukemHealth and Human Development Research Network, Douala, Cameroon.
Université de Yaoundé I · CMHealth and Human Development (2HD) Research Network · CMUniversity of Douala · CMUniversity of Lausanne · CHUniversity Teaching Hospital of Yaounde · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies report high levels of inflammatory markers in women with polycystic ovary syndrome (PCOS), reflecting chronic low-grade inflammation. This inflammation is thought to be associated with insulin resistance. We aim to evaluate inflammatory markers [high sensitivity C reactive protein (CRP) and interleukin 6] and insulin resistance in women with PCOS in Yaoundé, Cameroon.

methodsWe conducted a comparative cross-sectional study including 32 women with PCOS aged between 18 and 44 years and 32 controls matched for age and body mass index (BMI). Homeostasis model assessment of insulin resistance (HOMA-IR) index calculated using C peptide levels was used to evaluate insulin resistance. Serum levels of high sensitivity CRP (hsCRP) and interleukin 6 (IL-6) were measured. Comparisons were made using the Student's

resultsWe found that the median [25th-75th percentile] level of hsCRP was significantly higher in women with PCOS compared to the controls (0.63 [0.32-3.81] mg/L

conclusionPCOS is associated with an increased level of hsCRP and insulin resistance in Cameroonian women. This exploratory study provides baseline evidence for larger-scale studies.

Indexed as

high sensitivity C reactive proteininsulin resistanceinterleukin 6polycystic ovary syndromesub-Saharan Africa

Identifiers

PMID34552346
PMCPMC8450186
OpenAlexW3200475976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.