Evidence map›Paper›PMID 34552312›Full record

ArticlePhysics of fluids (Woodbury, N.Y. : 1994)2021

How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.

Mohammad S Islam, Puchanee Larpruenrudee, Suvash C Saha, Oveis Pourmehran, Akshoy Ranjan Paul, Tevfik Gemci, Richard Collins, Gunther Paul, Yuantong Gu

Abstract read
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In one paragraph

Article in Physics of fluids (Woodbury, N.Y. : 1994), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Exposure to SARS-CoV-2 and Infantile Diseases.Global medical genetics · 2023
    Article
  6. Investigation of tracer gas transport in a new numerical model of lung acini.Medical & biological engineering & computing · 2022
    Article
  7. Is the SARS CoV-2 Omicron Variant Deadlier and More Transmissible Than Delta Variant?International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad S IslamSchool of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, New South Wales 2007, Australia.ORCID https://orcid.org/0000-0001-6264-3886
Puchanee LarpruenrudeeSchool of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, New South Wales 2007, Australia.ORCID https://orcid.org/0000-0002-3413-3667
Suvash C SahaSchool of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, New South Wales 2007, Australia.ORCID https://orcid.org/0000-0002-9962-8919
Oveis PourmehranSchool of Mechanical Engineering, The University of Adelaide, Adelaide, South Australia 5005, Australia and Department of Surgery-Otolaryngology Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Akshoy Ranjan PaulDepartment of Applied Mechanics, Motilal Nehru National Institute of Technology Allahabad, Prayagraj 211004, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-8772-0988
Tevfik GemciBraun Medical, Irvine, California 92614, USA.ORCID https://orcid.org/0000-0002-6424-2442
Richard CollinsBiomechanics International, Cranberry Township, Pennsylvania 16066, USA.
Gunther PaulJames Cook University, Australian Institute of Tropical Health and Medicine, Townsville, Queensland 4810, Australia.ORCID https://orcid.org/0000-0002-1880-9161
Yuantong GuSchool of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane 4000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent outbreak of the COVID-19 causes significant respirational health problems, including high mortality rates worldwide. The deadly corona virus-containing aerosol enters the atmospheric air through sneezing, exhalation, or talking, assembling with the particulate matter, and subsequently transferring to the respiratory system. This recent outbreak illustrates that the severe acute respiratory syndrome (SARS) coronavirus-2 is deadlier for aged people than for other age groups. It is evident that the airway diameter reduces with age, and an accurate understanding of SARS aerosol transport through different elderly people's airways could potentially help the overall respiratory health assessment, which is currently lacking in the literature. This first-ever study investigates SARS COVID-2 aerosol transport in age-specific airway systems. A highly asymmetric age-specific airway model and fluent solver (ANSYS 19.2) are used for the investigation. The computational fluid dynamics measurement predicts higher SARS COVID-2 aerosol concentration in the airway wall for older adults than for younger people. The numerical study reports that the smaller SARS coronavirus-2 aerosol deposition rate in the right lung is higher than that in the left lung, and the opposite scenario occurs for the larger SARS coronavirus-2 aerosol rate. The numerical results show a fluctuating trend of pressure at different generations of the age-specific model. The findings of this study would improve the knowledge of SARS coronavirus-2 aerosol transportation to the upper airways which would thus ameliorate the targeted aerosol drug delivery system.

Identifiers

PMID34552312
PMCPMC8450910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.