Evidence map›Paper›PMID 34552243›Full record

ArticleNature2021

Structural basis of gating modulation of Kv4 channel complexes.

Yoshiaki Kise, Go Kasuya, Hiroyuki H Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo, Osamu Nureki

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Interpretable scRNA-seq Analysis with Intelligent Gene Selection.Applied biochemistry and biotechnology · 2026
    Article
  2. Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. KChIP4a is a Biophysical Amplifier of Inhibition in Atypical Dopamine Neurons and Controls Learning from Negative Prediction Errors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Voltage sensors.Molecular pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshiaki Kise *Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. yoshiaki.kise@bs.s.u-toyko.ac.jp.ORCID http://orcid.org/0000-0002-1840-5028
Go Kasuya *Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke, Japan. gokasuya@jichi.ac.jp.ORCID http://orcid.org/0000-0003-1756-5764
Hiroyuki H OkamotoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Daichi YamanouchiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Kan KobayashiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Tsukasa KusakizakoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6186-6647
Tomohiro NishizawaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7463-8398
Koichi NakajoDivision of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke, Japan.ORCID http://orcid.org/0000-0003-0766-7281
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0003-1813-7008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart

Indexed as

Cryoelectron MicroscopyIon Channel GatingAnimalsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesFemaleHumansKv Channel-Interacting ProteinsModels, MolecularMultiprotein ComplexesMutationNerve Tissue ProteinsOocytesPotassium ChannelsProtein BindingShal Potassium ChannelsXenopus laevisDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDPP6 protein, humanKCNIP1 protein, humanKv Channel-Interacting ProteinsMultiprotein ComplexesNerve Tissue ProteinsPotassium ChannelsShal Potassium Channels

Identifiers

PMID34552243
PMCPMC8566240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.