Evidence map›Paper›PMID 34552219›Full record

ReviewNature chemical biology2021

Escherichia coli small molecule metabolism at the host-microorganism interface.

Alexandra Gatsios, Chung Sub Kim, Jason M Crawford

Open access · greenAbstract readReview
In one paragraph

Review in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Deciphering the Implications ofPathogens (Basel, Switzerland) · 2026
    Review
  4. Diversity of Bacteria.Progress in molecular and subcellular biology · 2026
    Review
  5. Avian PathogenicVeterinary sciences · 2025
    Review
  6. Article
  7. Lead-free perovskite KCsSnIScientific reports · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Coupled Effect of Nutritional Food Molecules andFoods (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Review
  19. Cellular Stress-Induced Metabolites inJournal of natural products · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Alexandra GatsiosDepartment of Chemistry, Yale University, New Haven, CT, USA.
Chung Sub KimDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-9961-4093
Jason M CrawfordDepartment of Chemistry, Yale University, New Haven, CT, USA. jason.crawford@yale.edu.ORCID http://orcid.org/0000-0002-7583-1242
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Structural and functional studies of colibactinR01CA215553 · NCI · YALE UNIVERSITY · PI Seth B. Herzon, Christian Jobin · 2018 to 2026
$5.5M
EPA EP-W-17-011NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA215553
6 · The paper itself

Abstract

Escherichia coli are a common component of the human microbiota, and isolates exhibit probiotic, commensal and pathogenic roles in the host. E. coli members often use diverse small molecule chemistry to regulate intrabacterial, intermicrobial and host-bacterial interactions. While E. coli are considered to be a well-studied model organism in biology, much of their chemical arsenal has only more recently been defined, and much remains to be explored. Here we describe chemical signaling systems in E. coli in the context of the broader field of metabolism at the host-bacteria interface and the role of this signaling in disease modulation.

Indexed as

Escherichia coliGene Expression Regulation, BacterialHost Microbial InteractionsHumansMicrobiotaProbiotics

Identifiers

PMID34552219
PMCPMC8675634
OpenAlexW3200755282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.