Evidence map›Paper›PMID 34552118›Full record

Trial reportScientific reports2021

A pilot study shows the positive effects of continuous airway pressure for treating hypernasal speech in children with infantile-onset Pompe disease.

Yin-Ting Zeng, Wen-Yu Liu, Pao-Chuan Torng, Wuh-Liang Hwu, Ni-Chung Lee, Chun-Yi Lin, Yin-Hsiu Chien

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yin-Ting ZengDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
Wen-Yu LiuDepartment of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Pao-Chuan TorngDepartment of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Wuh-Liang HwuDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
Ni-Chung LeeDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Yi LinDepartment of Audiology and Speech-Language Pathology, Asia University, Taichung, Taiwan.
Yin-Hsiu ChienDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan. chienyh@ntu.edu.tw.
Chang Gung University · TWNational Taiwan University · TWAsia University · TWNational Taipei University of Nursing and Health Science · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with infantile-onset Pompe disease (IOPD) demonstrate hypernasality. This study aimed to evaluate whether continuous positive airway pressure (CPAP) training may reduce hypernasality in children with IOPD. Five children with IOPD were enrolled in a single-subject experimental design of type A-B-A'. The intervention comprised an 8-week, 6-day-per-week regimen of CPAP training at home. Participants continued traditional speech therapy once per week throughout the 24-week study duration. The outcome measurements included the degree of hypernasality (DH), the percentage of consonants correct (PCC), and the speech intelligibility score (SIS). C-statistic analysis with an α of 0.05 was used along with visual analysis to assess speech changes. Three patients completed the study. During the CPAP training phase, the DH, PCC, and SIS were significantly improved compared with the baseline (p < 0.05). At the follow-up phase, both DH and SIS were improved compared with the baseline (p < 0.05), but the PCC had returned to the baseline level. CPAP training demonstrated effectiveness in reducing nasal sounds in IOPD patients. Further studies training younger children with normal hearing may help elucidate the persistence of the effects in children with IOPD.

Indexed as

Continuous Positive Airway PressureArticulation DisordersChildChild, PreschoolCross-Over StudiesFemaleGlycogen Storage Disease Type IIHumansMalePilot ProjectsSpeech IntelligibilitySpeech Therapy

Identifiers

PMID34552118
PMCPMC8458442
OpenAlexW3199439319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.