ArticleNature communications2021
Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
48 citing papers in PubMed, 121 citations in OpenAlex.
- Superparamagnetic Biomembranes for Dynamic Nanoparticle and Molecular Patterning.Nano letters · 2026Article
- Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.Advanced healthcare materials · 2026Article
- Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Magnetoelectric Nanoparticle-Based Wireless Brain-Computer Interface: Underlying Physics and Projected Technology Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation.Nature communications · 2026Article
- NIR-Triggered Upconversion-Perovskite Heterostructures for Non-Genetic, Implant-Free Optoelectronic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia-Reperfusion Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advancing neural interfaces: a framework for the fabrication and characterization of freestanding micro-nanodevices.Microsystems & nanoengineering · 2026Article
- Enhancing colloidal stability of anisotropic magnetic nanodiscs through mesoporous silica and P(NIPAM/MAA) copolymer coatings.Nanoscale · 2026Article
- Biocompatible PVDF Nanofibers with Embedded Magnetite Nanodiscs Enable Wireless Magnetoelectric Stimulation in Premotor Cortex.Advanced healthcare materials · 2025Article
- Nanoparticle-mediated magnetic hyperthermia in the treatment of neurological disorders.Nanomedicine (London, England) · 2025Review
- Wireless nonresonant stimulation of neurons on a magnetoelectric film surface.Science advances · 2025Article
- Functionalized Magnetic Nanoparticles: Can They Revolutionize the Treatment of Neurodegenerative Disorders?Materials (Basel, Switzerland) · 2025Review
- Magnetic-Driven Torque-Induced Electrical Stimulation for Millisecond-Scale Wireless Neuromodulation.Advanced healthcare materials · 2025Article
- Localized brain stimulation with mild magnetic hyperthermia promotes microglia activity towards reactive and autophagic phenotypes in vivo.Scientific reports · 2025Article
- Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Open-source magnetic system for wireless neuromodulations in vitro and for untethered brain stimulation in vivo.Scientific reports · 2025Article
- Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advances in magnetic field approaches for non-invasive targeting neuromodulation.Frontiers in human neuroscience · 2025Review
- Parallelized Mechanical Stimulation of Neuronal Calcium Through Cell-Internal Nanomagnetic Forces Provokes Lasting Shifts in the Network Activity State.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
Abstract
Deep brain stimulation (DBS) has long been used to alleviate symptoms in patients suffering from psychiatric and neurological disorders through stereotactically implanted electrodes that deliver current to subcortical structures via wired pacemakers. The application of DBS to modulate neural circuits is, however, hampered by its mechanical invasiveness and the use of chronically implanted leads, which poses a risk for hardware failure, hemorrhage, and infection. Here, we demonstrate that a wireless magnetothermal approach to DBS (mDBS) can provide similar therapeutic benefits in two mouse models of Parkinson's disease, the bilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and in the unilateral 6-hydroxydopamine (6-OHDA) model. We show magnetothermal neuromodulation in untethered moving mice through the activation of the heat-sensitive capsaicin receptor (transient receptor potential cation channel subfamily V member 1, TRPV1) by synthetic magnetic nanoparticles. When exposed to an alternating magnetic field, the nanoparticles dissipate heat, which triggers reversible firing of TRPV1-expressing neurons. We found that mDBS in the subthalamic nucleus (STN) enables remote modulation of motor behavior in healthy mice. Moreover, mDBS of the STN reversed the motor deficits in a mild and severe parkinsonian model. Consequently, this approach is able to activate deep-brain circuits without the need for permanently implanted hardware and connectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.