ArticleBrain and behavior2021
Clinical features and related factors of freezing of gait in patients with Parkinson's disease.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.Movement disorders clinical practice · 2024Pooled it
- Spinal cord stimulation therapy for gait impairment in Parkinson's disease: a double-blinded, randomised feasibility trial with an open extension.Nature communications · 2026Trial
- Freezing of Gait in Parkinson's Disease: A Heterogeneous Phenomenon Across Assessment Tools.The European journal of neuroscience · 2026Article
- Association Between Freezing of Gait and Sleep Quality in People with Parkinson's Disease.Brain sciences · 2026Article
- Identifying gait characteristics associated with freezing of gait in Parkinson's disease: An analysis of on and off medication states.Gait & posture · 2025Article
- The Role of Aquaporin-4 in Freezing of Gait and Dynamic Balance Learning in Parkinson's Disease.Scientific reports · 2025Article
- Predictive model for the therapeutic effect of bilateral subthalamic nucleus deep brain stimulation on the freezing of gait in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- The impact of fatigue severity and depression level on the quality of life in individuals with Parkinson's disease in Taiwan.Frontiers in psychiatry · 2024Article
- Assessment of the psychometric properties of the Italian version of the New Freezing of Gait Questionnaire (NFOG-Q-IT) in people with Parkinson disease: a validity and reliability study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease.Frontiers in genetics · 2022Article
- Clinical features and related factors of freezing of gait in patients with Parkinson's disease.Brain and behavior · 2021Article
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9 authors.
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Abstract
backgroundFreezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients' quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge. The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD).
methodsThe motor and nonmotor symptoms of a total number of 77 PD patients were evaluated. Patients with or without FOG were defined as a score ≥1 in the new freezing of gait questionnaire (NFOG-Q). A comparative study between patients with and without FOG was conducted.
resultsIn this investigation, the prevalence of FOG was 48%. The patients with FOG had longer disease duration, higher Hoehn-Yahr stage (H-Y stage), higher dose of dopaminergic agents, and higher nonmotor and motor symptom scores. A significant positive correlation was found between the NFOG-Q score and the H-Y stage, PIGD subscore, PDQ-39, and the attention/memory in the nonmotor symptoms assessment scale (NMSS) subitem (r > 0.5, p < .05). The binary logistic regression analysis showed that the higher H-Y stage, higher rigidity subscore and Unified Parkinson's Disease Rating Scale II (UPDRS II) score, and UPDRS III score were significantly correlated with the occurrence of FOG (p < .05). In the analysis of the frequency of FOG, the prevalence of FOG in H-Y stage was higher in the middle and late stages, and the prevalence of FOG increased with the increase in PDQ-39 scores.
conclusionThe severity of FOG was significantly positively correlated with the H-Y stage, PIGD subscore, PDQ-39 score, and attention/memory score. Based on our findings, we conclude that the clinical characteristics of rigidity can be used as a potential predictor of FOG.
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