ArticleCell reports2021
A long-range, recurrent neuronal network linking the emotion regions with the somatic motor cortex.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
- Naltrexone treatment improves anxiety- and depression-like behavior in alcohol-exposed mice.Behavioural pharmacology · 2026Article
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- Modulation of cortical representations of sensory and contextual information underlies aversive associative learning.Cell reports · 2024Article
- A prefrontal motor circuit initiates persistent movement.Nature communications · 2024Article
- Imaging distinct neuronal populations with a dual channel miniscope.Frontiers in neuroscience · 2024Article
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals.PLoS biology · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Recurrent neural networks (RNNs) are designed to learn sequential patterns in silico, but it is unclear whether and how an RNN forms in the native networks of the mammalian brain. Here, we report an innate RNN, which is formed by the unidirectional connections from three basic units: input units arriving from emotion regions, a hidden unit in the medial prefrontal cortex (mPFC), and output units located at the somatic motor cortex (sMO). Specifically, the neurons from basal lateral amygdala (BLA) and the insular cortex (IC) project to the mPFC motor-cortex-projecting (MP) neurons. These MP neurons form a local self-feedback loop and target major projecting neurons of the sMO. Within the sMO, the neurons in the infragranular layers receive stronger input than the neurons in supragranular layers. Finally, we show in vivo evidence that the communications from the emotion regions to the sMO are abolished when MP neurons are chemogenetically silenced.
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