Evidence map›Paper›PMID 34551193›Full record

ArticleCNS neuroscience & therapeutics2021

The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case-control study in the Chinese population.

Xuewen Xiao, Lina Guo, Xinxin Liao, Yafang Zhou, Weiwei Zhang, Lu Zhou, Xin Wang, Xixi Liu, Hui Liu, Tianyan Xu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Identification of highly potent and selective HTRA1 inhibitors.Bioorganic & medicinal chemistry letters · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Xuewen XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lina GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xinxin LiaoNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Yafang ZhouNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Weiwei ZhangNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Lu ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xin WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xixi LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hui LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tianyan XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yuan ZhuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qijie YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiaoli HaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yingzi LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Junling WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5117-5204
Jinchen LiNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
Bin JiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-3393-8578
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe role of vascular dementia (VaD)-associated genes in Alzheimer's disease (AD) remains elusive despite similar clinical and pathological features. We aimed to explore the relationship between these genes and AD in the Chinese population.

methodsEight VaD-associated genes were screened by a targeted sequencing panel in a sample of 3604 individuals comprising 1192 AD patients and 2412 cognitively normal controls. Variants were categorized into common variants and rare variants according to minor allele frequency (MAF). Common variant (MAF ≥ 0.01)-based association analysis was conducted by PLINK 1.9. Rare variant (MAF < 0.01) association study and gene-based aggregation testing of rare variants were performed by PLINK 1.9 and Sequence Kernel Association Test-Optimal (SKAT-O test), respectively. Age at onset (AAO) and Mini-Mental State Examination (MMSE) association studies were performed with PLINK 1.9. Analyses were adjusted for age, gender, and APOE ε4 status.

resultsFour common COL4A1 variants, including rs874203, rs874204, rs16975492, and rs1373744, exhibited suggestive associations with AD. Five rare variants, NOTCH3 rs201436750, COL4A1 rs747972545, COL4A1 rs201481886, CST3 rs765692764, and CST3 rs140837441, showed nominal association with AD risk. Gene-based aggregation testing revealed that HTRA1 was nominally associated with AD. In the AAO and MMSE association studies, variants in GSN, ITM2B, and COL4A1 reached suggestive significance.

conclusionCommon variants in COL4A1 and rare variants in HTRA1, NOTCH3, COL4A1, and CST3 may be implicated in AD pathogenesis. Besides, GSN, ITM2B, and COL4A1 are probably involved in the development of AD endophenotypes.

Indexed as

AgedAlzheimer DiseaseCase-Control StudiesChinaDementia, VascularEndophenotypesFemaleHumansMaleMiddle AgedAlzheimer's diseaseChinese populationgenesvascular dementia

Identifiers

PMID34551193
PMCPMC8611771
OpenAlexW3199935306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.