ArticleAngewandte Chemie (International ed. in English)2021
Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Wavelength-Dependent 3D Printing: Introducing 3D Printed Action Plots.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Electroresponsive Thiol-Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control.ACS applied polymer materials · 2024Article
- Michael Addition-Elimination Ring-Opening Polymerization.Journal of the American Chemical Society · 2024Article
- Polymeric Hydrogels for Intervertebral Disc Replacement/Integration: Playing with the Chemical Composition for Tuning Shear Behavior and Hydrophilicity.Gels (Basel, Switzerland) · 2023Article
- Crosslinker structure modulates bulk mechanical properties and dictates hMSC behavior on hyaluronic acid hydrogels.Acta biomaterialia · 2023Article
- Click Step-Growth Polymerization andAccounts of chemical research · 2022Article
- Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at the cost of changing another parameter, that in turn affects the physical properties of the material and ultimately influences the cellular response. Herein, we report that by manipulating the stereochemistry of a double bond, formed in situ during gelation, materials with diverse mechanical properties but comparable physical properties can be obtained. Click-hydrogels that possess a high % trans content are stiffer than their high % cis analogues by almost a factor of 3. Human mesenchymal stem cells acted as a substrate stiffness cell reporter demonstrating the potential of these platforms to study mechanotransduction without the influence of other external factors.
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Registered trials
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