ArticleBlood advances2021
Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018.
Article in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Impact of Point-of-care Allogeneic Red Blood Cell Washing on Markers of Transfusion-related Respiratory Complications: A Phase II Randomized Clinical Trial.Anesthesiology · 2025Trial
- Blood transfusion in pediatric sepsis-associated acute kidney injury: a nationwide study of risk factors and outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Trends in cryoprecipitate transfusion in the United States.Transfusion · 2026Article
- Have we reached a new baseline for blood collection and transfusion in the United States? National Blood Collection and Utilization Survey, 2023.Transfusion · 2026Article
- Analysis of the incidence and risk factors of blood transfusion in robot-assisted laparoscopic total hysterectomy: a retrospective nationwide inpatient sample database study.Perioperative medicine (London, England) · 2025Article
- The untransfusable patient.Hematology. American Society of Hematology. Education Program · 2025Review
- In vitro and in vivo evaluation of leukoreduced red blood cells after automated separation of whole blood.Transfusion · 2025Article
- Hospitalizations with blood transfusions and transfusion-related adverse events in US acute care hospitals, 2016-2020.Transfusion · 2025Article
- Blood transfusion in percutaneous left atrial appendage occlusion: a nationwide analysis of incidence, predictors, and outcomes.BMC cardiovascular disorders · 2025Article
- "Are my blood products coming?": Implementation of a novel blood product tracker in the electronic health record system.Transfusion · 2025Article
- Cost Reduction in Blood Transfusions After Implementation of Decision Protocol Based on Hemoglobin and Anemia Symptoms: A Pre-Post Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- The global blood donation index: an imperfect measure of transfusion need.Lancet (London, England) · 2024Review
- Maternal red blood cell alloimmunization prevalence in the United States.Blood advances · 2024Article
- Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery.JAMA network open · 2024Article
- Continued stabilization of blood collections and transfusions in the United States: Findings from the 2021 National Blood Collection and Utilization Survey.Transfusion · 2023Article
- Patient Blood Management after Hematopoietic Stem Cell Transplantation in a Pediatric Setting: Starting Low and Going Lower.Diagnostics (Basel, Switzerland) · 2023Article
- Trends of Blood Transfusion According to Diseases in Korea: A 10-Year Nationwide Cohort Study.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Managing blood supplies during natural disasters, humanitarian emergencies, and pandemics: lessons learned from COVID-19.Expert review of hematologyReview
- Donor health beyond donation: cardiovascular risk factors in blood donor populations. A cross-sectional study.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Blood transfusions are among the most common therapeutic procedures performed in hospitalized patients. This study evaluates contemporary national trends in red blood cell (RBC), plasma, platelet, and cryoprecipitate transfusions. National Inpatient Sample, the largest all-payer inpatient database representing 94% to 97% of the US population, was evaluated from the fourth quarter (Q4) of 2015 through 2018. Quarterly trends for the percentage of hospitalizations with a transfusion procedure were separately examined for each blood product using log binomial regression and reported as quarterly percent change (QPC). The percentage of hospitalizations with an RBC transfusion decreased from 4.22% (2015Q4) to 3.79% (2018Q4) (QPC = -0.72; 95% confidence interval [CI], -1.26 to -0.19; Ptrend = .008). Although plasma transfusions also decreased, QPC = -1.33 (95% CI, -2.00 to -0.65; Ptrend < .001), platelet transfusions remained stable QPC = -0.13 (95% CI, -0.99 to 0.73; Ptrend = .766). In contrast, hospitalizations with cryoprecipitate utilization significantly increased QPC = 2.01 (95% CI, 0.57 to 3.44; Ptrend = .006). Significant quarterly reductions in RBC transfusions were also seen among many, but not all, strata of sex, race/ethnicity, patient risk severity, and admission type (elective vs nonelective). Despite significant declines in RBC transfusions among older adults, there were no significant changes among pediatric age-group (<18 years) and those 18 to 49 years. The decline in RBC and plasma transfusions suggests steady incorporation of robust evidence base showing safety of restrictive transfusions. Increased cryoprecipitate use may be reflective of wider adoption of hypofibrinogenemia management and hemostasis testing for coagulopathic patients.
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