Evidence map›Paper›PMID 34550834›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Changes in synaptic density in the subacute phase after ischemic stroke: A

Laura Michiels, Nathalie Mertens, Liselot Thijs, Ahmed Radwan, Stefan Sunaert, Mathieu Vandenbulcke, Geert Verheyden, Michel Koole, Koen Van Laere, Robin Lemmens

Open access · greenAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Exploring synaptic density patterns in cerebral small vessel disease: insights from [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Article
  5. Article
  6. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. GMP-compliant automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2024
    Article
  8. Review
  9. Review
  10. Article
  11. In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  12. Review
  13. Review
  14. Impact of meningeal uptake and partial volume correction techniques on [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  15. Imaging of Synaptic Density in Neurodegenerative Disorders.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura MichielsDepartment of Neurosciences, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1208-5334
Nathalie MertensNuclear Medicine and Molecular Imaging, 26657KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-2409-7586
Liselot ThijsDepartment of Rehabilitation Sciences, 26657KU Leuven, KU Leuven, Leuven, Belgium.
Ahmed RadwanTranslational MRI, 26657KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Stefan SunaertTranslational MRI, 26657KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1177-4680
Mathieu VandenbulckeVIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
Geert VerheydenDepartment of Rehabilitation Sciences, 26657KU Leuven, KU Leuven, Leuven, Belgium.
Michel KooleNuclear Medicine and Molecular Imaging, 26657KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Koen Van LaereNuclear Medicine and Molecular Imaging, 26657KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Robin LemmensDepartment of Neurosciences, KU Leuven, Leuven, Belgium.
KU Leuven · BEVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional alterations after ischemic stroke have been described with Magnetic Resonance Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on

Indexed as

CerebellumIschemic StrokePositron-Emission TomographyAdultAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsPyridinesPyrrolidinones1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinonesSV2A protein, humanIschemic strokemolecular imagingpositron emission tomographySV2Asynaptic density

Identifiers

PMID34550834
PMCPMC9122519
OpenAlexW3199788586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.