Evidence map›Paper›PMID 34550818›Full record

Observational studyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Occult blood flow patterns distal to an occluded artery in acute ischemic stroke.

Nerea Arrarte Terreros, Bettine G van Willigen, Wera S Niekolaas, Manon L Tolhuisen, Josje Brouwer, Jonathan M Coutinho, Ludo Fm Beenen, Charles Blm Majoie, Ed van Bavel, Henk A Marquering

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Exploring ischemic core growth rate and endovascular therapy benefit in large core patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nerea Arrarte TerrerosDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.ORCID 0000-0002-9912-7508
Bettine G van WilligenDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Wera S NiekolaasDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Manon L TolhuisenDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.ORCID 0000-0002-2695-1117
Josje BrouwerDepartment of Neurology, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Ludo Fm BeenenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Charles Blm MajoieDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.ORCID 0000-0002-7600-9568
Ed van BavelDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
Henk A MarqueringDepartment of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Residual blood flow distal to an arterial occlusion in patients with acute ischemic stroke (AIS) is associated with favorable patient outcome. Both collateral flow and thrombus permeability may contribute to such residual flow. We propose a method for discriminating between these two mechanisms, based on determining the direction of flow in multiple branches distal to the occluding thrombus using dynamic Computed Tomography Angiography (dynamic CTA). We analyzed dynamic CTA data of 30 AIS patients and present patient-specific cases that identify typical blood flow patterns and velocities. We distinguished patterns with anterograde (N = 10), retrograde (N = 9), and both flow directions (N = 11), with a large variability in velocities for each flow pattern. The observed flow patterns reflect the interplay between permeability and collaterals. The presented method characterizes distal flow and provides a tool to study patient-specific distal tissue perfusion.

Indexed as

Cerebral AngiographyCerebral ArteriesCollateral CirculationComputed Tomography AngiographyIschemic StrokeAgedBlood Flow VelocityHumansMaleMiddle AgedAcute ischemic strokeblood flow quantificationcollateral circulationdynamic CTAthrombus permeability

Identifiers

PMID34550818
PMCPMC8795216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.