ArticleScience advances2021
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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72citing papers in PubMed, 1 pooled it
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Diurnal Transcriptomics in Mouse Liver Reveals Low Repeatability of Rhythm Analyses.Journal of biological rhythms · 2023Pooled it
- Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- You are when you eat: How food synchronizes liver clocks.Science advances · 2026Review
- mTOR signaling contributes to system-driven rhythmic gene expression in mouse liver.Science advances · 2026Article
- Perturbation of the circadian rhythmic transcription contributes to radiotherapy-induced salivary gland hypofunction.Communications biology · 2026Article
- D-Box Binding Protein (DBP) as a Circadian Output Regulator: Molecular Mechanisms, Tissue-Specific Functions, and Disease Relevance.International journal of molecular sciences · 2026Review
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- NR5A2 controls gene expression and chromatin contacts of essential circadian metabolic genes in the liver.Cellular and molecular life sciences : CMLS · 2026Article
- Multi-Omics Landscape of Circadian Clock Dysregulation Across the Chronic Liver Disease Spectrum.International journal of molecular sciences · 2026Review
- The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function.Journal of biological rhythms · 2026Article
- The Cardiac Circadian Clock Regulates Rhythms in Peripheral Tissues via Fibulin 5.Comprehensive physiology · 2026Article
- Circadian clock gates diurnal glucose utilization.PLoS biology · 2026Article
- Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Dietary rhythms and biological aging risk across multiple organs.NPJ science of food · 2026Article
- Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon.Science advances · 2026Article
- Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases.Endocrine journal · 2026Review
- Loss, amplification or mistiming of the daily rhythms of metabolic markers in patients with cirrhosis.JHEP reports : innovation in hepatology · 2026Article
- Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea.Science advances · 2026Article
- Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors.
Carolina M GrecoCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-9895-5635
Kevin B KoronowskiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6808-1789
Jacob G SmithCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-5139-1054
Jiejun ShiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9777-1183
Paolo KunderfrancoBioinformatics Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano 20089, Italy.ORCID 0000-0001-7477-8710
Roberta CarrieroBioinformatics Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano 20089, Italy.ORCID 0000-0001-8619-6152
Siwei ChenInstitute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Muntaha SamadInstitute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Patrick-Simon WelzInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.ORCID 0000-0001-8370-625X
Valentina M ZinnaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.ORCID 0000-0002-1693-5914
Thomas MortimerInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
Sung Kook ChunCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Kohei ShimajiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-8121-7257
Tomoki SatoCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Paul PetrusCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Arun KumarDepartment of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain.
Mireia Vaca-DempereDepartment of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain.ORCID 0000-0002-9804-2924
Oleg DeryaginDepartment of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain.ORCID 0000-0003-0903-7785
Cassandra VanCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
José Manuel Monroy KuhnGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Dominik LutterGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-8800-0683
Marcus M SeldinCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8026-4759
Selma MasriCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-8619-8331
Wei LiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9931-5990
Pierre BaldiInstitute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.ORCID 0000-0001-8752-4664
Kenneth A DyarGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-9010-8757
Pura Muñoz-CánovesDepartment of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain.ORCID 0000-0002-7533-9047
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.ORCID 0000-0002-9059-5049
Paolo Sassone-CorsiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MComputational and Experimental Modeling of Alternative PolyadenylationR01CA193466 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2016 to 2025
$3.3MIntegrative approaches to dissection of endocrine communicationDP1DK130640 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2021 to 2025
$3.2MTransfer: DNA Methylation Canyons in Human Cancers: Methods, Target Genes and Functional ConsequencesR01CA228140 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2019 to 2023
$2.8MBioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4MComputational and Experimental Modeling of Epigenetic DNA MethylationR01HG007538 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2014 to 2018
$1.9MA strategy for discovery of endocrine interactionsR00HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2020 to 2022
$745kHigh-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600kPacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600kHigh Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500kRewiring the Circadian Clock by FastingR21AG053592 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSONE-CORSI, PAOLO · 2017 to 2018
$425kNCI NIH HHS P30 CA062203NCI NIH HHS R01 CA193466NCI NIH HHS R01 CA228140NCI NIH HHS T32 CA009054NCRR NIH HHS S10 RR025496NHGRI NIH HHS R01 HG007538NHLBI NIH HHS K99 HL138193NHLBI NIH HHS R00 HL138193NIA NIH HHS R21 AG053592NIDDK NIH HHS DP1 DK130640NIDDK NIH HHS F32 DK121425NIDDK NIH HHS R21 DK114652NIGMS NIH HHS R01 GM123558NIH HHS S10 OD010794NIH HHS S10 OD021718
Abstract
The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of the lack of specialized animal models, it is unclear how tissue clocks interact with extrinsic signals to drive molecular oscillations. Here, we isolated the interaction between feeding and the liver clock by reconstituting Bmal1 exclusively in hepatocytes (Liver-RE), in otherwise clock-less mice, and controlling timing of food intake. We found that the cooperative action of BMAL1 and the transcription factor CEBPB regulates daily liver metabolic transcriptional programs. Functionally, the liver clock and feeding rhythm are sufficient to drive temporal carbohydrate homeostasis. By contrast, liver rhythms tied to redox and lipid metabolism required communication with the skeletal muscle clock, demonstrating peripheral clock cross-talk. Our results highlight how the inner workings of the clock system rely on communicating signals to maintain daily metabolism.
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