Evidence map›Paper›PMID 34550553›Full record

ArticleJournal of natural medicines2022

Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase.

Yusuke Hirasawa, Tomoko Tanaka, Shiro Hirasawa, Chin Piow Wong, Nahoko Uchiyama, Toshio Kaneda, Yukihiro Goda, Hiroshi Morita

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Serramyuines A-C, new skeletal CJournal of natural medicines · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Cryptadine C, a new CJournal of natural medicines · 2023
    Article
  6. Article
  7. Amaryllidaceae Alkaloids fromPlants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yusuke HirasawaFaculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan. y-hirasawa@hoshi.ac.jp.ORCID http://orcid.org/0000-0003-3610-4007
Tomoko TanakaFaculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Shiro HirasawaFaculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Chin Piow WongTokiwa Phytochemical Co., Ltd, 158, Kinoko, Sakura-shi, Chiba, 285-0801, Japan.
Nahoko UchiyamaNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku Kawasaki, Kanagawa, 210-9501, Japan.
Toshio KanedaFaculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Yukihiro GodaNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku Kawasaki, Kanagawa, 210-9501, Japan.
Hiroshi MoritaFaculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan. y-hirasawa@hoshi.ac.jp.
Hoshi University · JPNational Institute of Health Sciences · JP

Funding

japan society for the promotion of science JP19K07152
6 · The paper itself

Abstract

Cliniatines A-C (1-3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1-3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A-C showed moderate inhibitory activity against acetylcholinesterase.

Indexed as

AmaryllidaceaeAmaryllidaceae AlkaloidsAcetylcholinesteraseCholinesterase InhibitorsPlant ExtractsAcetylcholinesteraseAmaryllidaceae AlkaloidsCholinesterase InhibitorsPlant ExtractsAcetylcholinesteraseAmaryllidaceae alkaloidCliniatine AClivia miniata

Identifiers

PMID34550553
OpenAlexW3201264717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.