Evidence map›Paper›PMID 34550490›Full record

Observational studyGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2022

Survival analysis of a prospective multicenter observational study on surgical palliation among patients with malignant bowel obstruction caused by peritoneal dissemination of gastric cancer.

Ryohei Kawabata, Kazumasa Fujitani, Kentaro Sakamaki, Masahiko Ando, Yuichi Ito, Yutaka Tanizawa, Takanobu Yamada, Motohiro Hirao, Makoto Yamada, Jun Hihara and 8 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 16 institutions in 1 country.

Ryohei KawabataDepartment of Surgery, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Kita-ku, Sakai-city, , Osaka, 5918025, Japan. r-kawabata@umin.ac.jp.ORCID http://orcid.org/0000-0001-7386-1096
Kazumasa FujitaniDepartment of Gastroenterological Surgery, Osaka Prefectural General Medical Center, Osaka, Japan.
Kentaro SakamakiCenter for Data Science, Yokohama City University, Yokohama, Japan.
Masahiko AndoCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
Yuichi ItoDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Yutaka TanizawaDivision of Gastric Surgery, Shizuoka Cancer Center, Nagaizumi, Japan.
Takanobu YamadaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Motohiro HiraoDepartment of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Makoto YamadaDepartment of Surgery, Gifu Municipal Hospital, Gifu, Japan.
Jun HiharaDepartment of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan.
Ryoji
FukushimaDepartment of Surgery, Teikyo University School of Medicine, Itabashi City, Japan.
Yasuhiro ChodaDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Yasuhiro KoderaDepartment of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shin TeshimaDepartment of Surgery, National Hospital Organization Sendai Medical Center, Sendai, Japan.
Hisashi ShinoharaDepartment of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Masato KondoDepartment of Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
Kazuhiro YoshidaDepartment of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan.
Hiroshima City Asa Citizens Hospital · JPAichi Cancer Center · JPGifu Municipal Hospital · JPGifu University · JPHyogo Medical University · JPKanagawa Prefectural Hospital Organization · JPKobe City Medical Center General Hospital · JPNagoya University · JPNagoya University Hospital · JPOsaka National Hospital · JPOsaka Prefectural Medical Center · JPSakai Municipal Hospital · JPSendai Medical Center · JPShizuoka Cancer Center · JPTeikyo University · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur previous report showed that surgical palliation maintained quality of life (QOL), improved solid food intake, and had an acceptable surgical safety among patients with malignant bowel obstruction (MBO) caused by advanced gastric cancer. This study performed a survival analysis stratified by the patients' QOL to elucidate its impact on survival.

methodsPatients who underwent resection or bypass of the small intestine/colon or ileostomy/colostomy for bowel obstruction caused by peritoneal dissemination of gastric cancer were included. Validated instruments (EuroQoL-5 Dimensions) were used to assess QOL at baseline and 2 weeks, 1 month, and 3 months following surgical palliation. Postoperative improvement in oral intake was also evaluated using the Gastric Outlet Obstruction Scoring System (GOOSS). Univariate and multivariate survival analyses were performed using baseline characteristics and changes in QOL and GOOSS scores 2 weeks after surgery to determine prognostic factors.

resultsWe enrolled 60 patients with a median survival time of 6.64 (95% CI 4.76-10.28) months. Patients who received postoperative chemotherapy and had lower baseline C-reactive protein (CRP) levels, higher baseline albumin levels, better baseline EuroQoL-5 Dimensions (EQ-5D) scores, and improved oral intake after palliative surgery exhibited significantly better survival. Multivariate analysis identified postoperative chemotherapy, lower baseline CRP levels, and improved oral intake as independent prognostic factors.

conclusionsThe current study revealed that baseline QOL and postoperative QOL changes did not affect survival. Moreover, improved oral intake, lower baseline CRP levels, and postoperative chemotherapy were significant prognostic factors in patients who underwent palliative surgery for advanced gastric cancer with MBO.

Indexed as

Gastric Outlet ObstructionStomach NeoplasmsHumansPalliative CareProspective StudiesQuality of LifeRetrospective StudiesSurvival AnalysisGastric cancerMalignant bowel obstructionPalliative surgerySurvival

Identifiers

PMID34550490
OpenAlexW3199055330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.