Evidence map›Paper›PMID 34550467›Full record

ArticleEuropean journal of applied physiology2022

Bone mineral density in high-level endurance runners: Part B-genotype-dependent characteristics.

A J Herbert, A G Williams, S J Lockey, R M Erskine, C Sale, P J Hennis, S H Day, G K Stebbings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A J HerbertSchool of Health Sciences, Birmingham City University, Birmingham, UK. adam.herbert@bcu.ac.uk.ORCID http://orcid.org/0000-0001-8964-0087
A G WilliamsSports Genomics Laboratory, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, UK.
S J LockeyFaculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK.
R M ErskineSchool of Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.
C SaleMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
P J HennisMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
S H DaySchool of Medicine and Clinical Practice, University of Wolverhampton, Wolverhampton, UK.
G K StebbingsSports Genomics Laboratory, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInter-individual variability in bone mineral density (BMD) exists within and between endurance runners and non-athletes, probably in part due to differing genetic profiles. Certainty is lacking, however, regarding which genetic variants may contribute to BMD in endurance runners and if specific genotypes are sensitive to environmental factors, such as mechanical loading via training.

methodTen single-nucleotide polymorphisms (SNPs) were identified from previous genome-wide and/or candidate gene association studies that have a functional effect on bone physiology. The aims of this study were to investigate (1) associations between genotype at those 10 SNPs and bone phenotypes in high-level endurance runners, and (2) interactions between genotype and athlete status on bone phenotypes.

resultsFemale runners with P2RX7 rs3751143 AA genotype had 4% higher total-body BMD and 5% higher leg BMD than AC + CC genotypes. Male runners with WNT16 rs3801387 AA genotype had 14% lower lumbar spine BMD than AA genotype non-athletes, whilst AG + GG genotype runners also had 5% higher leg BMD than AG + GG genotype non-athletes.

conclusionWe report novel associations between P2RX7 rs3751143 genotype and BMD in female runners, whilst differences in BMD between male runners and non-athletes with the same WNT16 rs3801387 genotype existed, highlighting a potential genetic interaction with factors common in endurance runners, such as high levels of mechanical loading. These findings contribute to our knowledge of the genetic associations with BMD and improve our understanding of why some runners have lower BMD than others.

Indexed as

Polymorphism, Single NucleotideAdultAthletesBone DensityCase-Control StudiesFemaleGenotypeHumansMalePhenotypePhysical EnduranceReceptors, Purinergic P2X7RunningSex FactorsSurveys and QuestionnairesWnt ProteinsP2RX7 protein, humanReceptors, Purinergic P2X7WNT16 protein, humanWnt ProteinsBone mineral densityEnduranceGeneticsMarathonMechanical loadingSingle-nucleotide polymorphisms

Identifiers

PMID34550467
PMCPMC8748376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.