ArticleWorld journal of urology2022
Preoperative antibiotic therapy exceeding 7 days can minimize infectious complications after percutaneous nephrolithotomy in patients with positive urine culture.
Article in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Essential Japanese Guidelines for the Prevention of Perioperative Infections in the Urological Field: 2023 Edition.International journal of urology : official journal of the Japanese Urological Association · 2025Guideline
- International Alliance of Urolithiasis (IAU) guideline on staghorn calculi management.World journal of urology · 2024Guideline
- One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Effect of preoperative prophylactic antibiotic use on postoperative infection after percutaneous nephrolithotomy in patients with negative urine culture: a single-center randomized controlled trial.World journal of urology · 2023Trial
- A randomised controlled trial comparing two protocols of preoperative antibiotics in patients with positive urine culture undergoing percutaneous nephrolithotomy.World journal of urology · 2023Trial
- Impact of operative time on complications after PCNL in the elderly (aged ≥70 years): the Safety and Efficacy of Nephrolithotomy in Older patients undergoing PCNL (SENIOR-PCNL) study.BJU international · 2026Article
- Retroperitoneal laparoscopic pyelolithotomy as salvage therapy for refractory infectious renal calculi: A case report.Urology case reports · 2026Article
- Article
- A gender-based investigation of risk factors for infectious complications after percutaneous nephrolithotomy for kidney stones: insight for personalized management.World journal of urology · 2026Article
- The development and internal validation of a rating scale system in predicting renal stone bacteria culture positivity before PCNL: a cross-sectional study.Urolithiasis · 2026Article
- One-Day Aminoglycosides versus Three-Day Ceftazidime for Perioperative Prophylaxis and Postoperative Sepsis Risk in Patients with Urinary Calculi: A Propensity Score-Matched Retrospective Cohort Analysis.Drug design, development and therapy · 2026Article
- Vacuum-assisted mini-percutaneous nephrolithotomy is associated with lower rates of infectious complications compared to standard procedures in low-risk patients: a single-center experience.World journal of urology · 2025Article
- Targeted Antibiotic Prophylaxis in Percutaneous Nephrolithotomy: Results of a Protocol Based on Preoperative Urine Culture and Risk Assessment.Journal of clinical medicine · 2025Article
- Distribution characteristics of staghorn calculi bacteria and metabolic differences in patients of different genders.World journal of urology · 2025Article
- Is it necessary for patients with a positive urine culture to achieve a negative result after antimicrobial treatment before undergoing percutaneous nephrolithotomy?World journal of urology · 2025Article
- Nomogram including renal pelvic pressure to predict the occurrence of urosepsis following percutaneous nephrolithotomy: a dual center retrospective study of 1,448 patients.Translational andrology and urology · 2024Article
- Vacuum-assisted mini-percutaneous nephrolithotomy is associated with lower rates of infectious complications compared to vacuum-cleaner procedure in patients at high risk for infections: a single-center experience.World journal of urology · 2024Article
- Characteristics of Bacteria in Urine and Stones from Patients Treated with Percutaneous Nephrolithotomy and Association with Postoperative Infection.Infection and drug resistance · 2024Article
- Risk Factors for Systemic Inflammatory Response Syndrome After Percutaneous Transhepatic Cholangioscopic Lithotripsy.Journal of inflammation research · 2024Article
- Can we identify the risk factors for SIRS/sepsis after percutaneous nephrolithotomy? A meta‑analysis and literature review.Experimental and therapeutic medicine · 2023Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo explore an appropriate duration of antibiotic therapy before percutaneous nephrolithotomy (PCNL) in patients with positive urine culture.
methodsFrom March 2016 to May 2018, consecutive patients with positive urine culture undergoing PCNL were prospectively registered. Initial preoperative antibiotics were given empirically. If needed, antibiotics were upgraded or adjusted to susceptible antibiotic after obtaining antibiotic-sensitivity test. Postoperative systemic inflammatory response syndrome (SIRS) was the primary outcome.
resultsAmong the 220 participants, the incidence of positive stone culture and SIRS were 85.5% and 36.8%. Escherichia coli (53.6%, 44.5%) and Proteus mirabilis (8.2%, 10.0%) were the top two bacteria in urine and stones. In univariable analysis, patients with postoperative SIRS had a higher rate of stone culture positivity (97.5% VS 78.4%, P < 0.001) and a shorter duration of preoperative antibiotics therapy (3.4 ± 2.7 days versus 4.2 ± 2.8 days, P = 0.037). The landscape of SIRS showed a declining trend as the elongation of preoperative antibiotics (P = 0.039). In a day-by-day comparison, SIRS was less prevalent in patients treated by pre-PCNL antibiotics ≥ 7 days than in those with antibiotics ≤ 6 days (21.7% VS 40.8%, P = 0.017). Multivariable logistic regression confirmed positive stone culture (P = 0.001, OR 11.115) as an independent risk factor and pre-PCNL antibiotics ≥ 7 days (P = 0.048, OR 0.449) as an independent protective factor for SIRS. Preoperative antibiotic ≥ 7 days decreased SIRS from 45.4 to 27.8% and from 9.1 to 0% in patients with a positive and negative stone culture, respectively.
conclusionExceeding seven days should be appropriate duration of antibiotic therapy before PCNL in patients with positive urine cultures.
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