Evidence map›Paper›PMID 34550396›Full record

ArticleDer Urologe. Ausg. A2021

[Molecular diagnostics of bladder cancer-practical ramifications].

Gerald B Schulz, Christian G Stief, Matthias Saar, Thomas-Alexander Vögeli, Tilman Todenhöfer, Ruth Knüchel, Nadine T Gaisa

Abstract read
PubMed Publisher
In one paragraph

Article in Der Urologe. Ausg. A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Gerald B SchulzUrologische Klinik und Poliklinik, Klinikum der Universität München (LMU), München, Deutschland.
Christian G StiefUrologische Klinik und Poliklinik, Klinikum der Universität München (LMU), München, Deutschland.
Matthias SaarKlinik für Urologie und Kinderurologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.
Thomas-Alexander VögeliKlinik für Urologie, Uniklinik RWTH Aachen, Aachen, Deutschland.
Tilman TodenhöferStudienpraxis Urologie, Nürtingen, Deutschland.
Ruth KnüchelInstitut für Pathologie, Uniklinik RWTH Aachen, Aachen, Deutschland.
Nadine T GaisaInstitut für Pathologie, Uniklinik RWTH Aachen, Aachen, Deutschland. ngaisa@ukaachen.de.
Ludwig-Maximilians-Universität München · DEUniversitätsklinikum Aachen · DERWTH Aachen University · DEUniversitätsklinikum des Saarlandes · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the future, precision medicine with agents targeting specific genetic alterations will play an important role in bladder cancer. This includes both single genetic alterations (e.g. FGFR3) and gene panel analyses in patients with no further therapeutic options, rare cancer subtypes or unusual clinical courses. These molecular analyses can be carried out on formalin-fixed paraffin-embedded tumor samples and the results should be discussed in interdisciplinary molecular tumor boards in order to either recommend approved targeted therapies or suggest patients for molecular-based clinical trials, compassionate use programs or off-label use of drugs. The remuneration of molecular diagnostics is largely well-represented for the outpatient sector in Germany; however, the covering of treatment costs must currently be approved by the health insurances.

Indexed as

Urinary Bladder NeoplasmsGenetic TestingHumansMutationPathology, MolecularPrecision MedicineFibroblast growth factor receptorsMolecular tumor boardNext generation sequencingPrecision oncologyUrinary bladder neoplasms

Identifiers

PMID34550396
OpenAlexW3200972599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.