Evidence map›Paper›PMID 34550357›Full record

ArticleEndocrine reviews2022

Time-restricted Eating for the Prevention and Management of Metabolic Diseases.

Emily N C Manoogian, Lisa S Chow, Pam R Taub, Blandine Laferrère, Satchidananda Panda

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05730231 (Comparison of Calorie Restriction With Early Time-restricted Eating and Calorie Restriction With Mid-day Time-restricted Eating and Daily Calorie Restriction), which is not on this map. Cited by 211 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05730231 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of Calorie Restriction With Early Time-restricted Eating and Calorie Restriction With Mid-day Time-restricted Eating and Daily Calorie Restriction

TypeinterventionalSponsorUniversity of PrimorskaRan2023 to 2024Enrolled108ConditionsTime Restricted Feeding, Overweight and Obesity, Inflammation, HypercholesterolemiaArmsEffects of calorie restriction and time-restricted eating on human health
3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  20. Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Trial

151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily N C ManoogianSalk Institute for Biological Studies, La Jolla, California 92037, USA.
Lisa S ChowUniversity of Minnesota, Division of Diabetes, Endocrinology and Metabolism, Minneapolis, Minnesota 55455, USA.
Pam R TaubUniversity of California, San Diego, Division of Cardiovascular Diseases, Department of Medicine, 9434 Medical Center Drive, La Jolla, California 92037, USA.
Blandine LaferrèreNew York Nutrition Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center; New York, New York 10032, USA.
Satchidananda PandaSalk Institute for Biological Studies, La Jolla, California 92037, USA.ORCID 0000-0002-7855-0091

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
NIDDM PRIMARY PREVENTION TRIAL (DPT 2)U01DK048404 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1994 to 2021
$11.6M
Impact of Time-Restricted Feeding (TRF) on Glucose Homeostasis and Mitochondrial Function in Patients with Metabolic SyndromeR01DK118278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pam Rajendran Taub · 2018 to 2026
$5.3M
TREAT (Time Restricted EATing) to improve cardiometabolic healthR01AG065569 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAFERRERE, BLANDINE B · 2020 to 2024
$3.9M
Optimized Circadian Rhythms for the Prevention of Alzheimer's DiseaseRF1AG068550 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MELKANI, GIRISH C., PANDA, SATCHIDANANDA · 2020 to 2020
$3.0M
Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese HumansR01DK124484 · NIDDK · UNIVERSITY OF MINNESOTA · PI CHOW, LISA SENYE · 2020 to 2023
$2.7M
Training Effects on Skeletal Muscle Lipid DynamicsR01DK098203 · NIDDK · UNIVERSITY OF MINNESOTA · PI CHOW, LISA SENYE · 2014 to 2018
$2.7M
Pharmacological targeting of circadian clock components to treat glioblastomaR01CA236352 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2019 to 2023
$2.6M
Diurnal rhythm in nutrient metabolism for metabolic homeostasisR01DK115214 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2018 to 2020
$2.5M
Molecular basis of circadian rhythms disruptions linked cardiometabolic disorders and their mitigation using dietary interventionR01AG065992 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MELKANI, GIRISH C. · 2019 to 2023
$1.9M
Optimized Circadian Rhythms for the Prevention of Alzheimer's DiseaseR01AG068550 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MELKANI, GIRISH C., PANDA, SATCHIDANANDA · 2024 to 2024
$736k
NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA236352NIA NIH HHS R01 AG065569NIA NIH HHS R01 AG065992NIA NIH HHS R01 AG068550NIA NIH HHS RF1 AG068550NIDDK NIH HHS R01 DK098203NIDDK NIH HHS R01 DK115214NIDDK NIH HHS R01 DK118278NIDDK NIH HHS R01 DK124484NIDDK NIH HHS U01 DK048404
6 · The paper itself

Abstract

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of the role of circadian rhythms in physiology and metabolism. In this approach, all calorie intake is restricted within a consistent interval of less than 12 hours without overtly attempting to reduce calories. This article will summarize the origin of TRF/TRE starting with concept of circadian rhythms and the role of chronic circadian rhythm disruption in increasing the risk for chronic metabolic diseases. Circadian rhythms are usually perceived as the sleep-wake cycle and dependent rhythms arising from the central nervous system. However, the recent discovery of circadian rhythms in peripheral organs and the plasticity of these rhythms in response to changes in nutrition availability raised the possibility that adopting a consistent daily short window of feeding can sustain robust circadian rhythm. Preclinical animal studies have demonstrated proof of concept and identified potential mechanisms driving TRF-related benefits. Pilot human intervention studies have reported promising results in reducing the risk for obesity, diabetes, and cardiovascular diseases. Epidemiological studies have indicated that maintaining a consistent long overnight fast, which is similar to TRE, can significantly reduce risks for chronic diseases. Despite these early successes, more clinical and mechanistic studies are needed to implement TRE alone or as adjuvant lifestyle intervention for the prevention and management of chronic metabolic diseases.

Indexed as

Cardiovascular DiseasesMetabolic DiseasesAnimalsCircadian RhythmFastingHumansObesityCircadian rhythmIntermittent fastingMetabolic disease MetabolismTime-restricted eatingTime-restricted feeding

Identifiers

PMID34550357
PMCPMC8905332

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.