ArticleCerebral cortex (New York, N.Y. : 1991)2022
Verbal and General IQ Associate with Supragranular Layer Thickness and Cell Properties of the Left Temporal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Accurate and well-powered case-control analysis of spatial molecular data.Nature methods · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
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- Neural Mechanisms of Shooting Preparation Under High-Risk and High-Precision Tasks: A Multiscale EEG Study.Brain and behavior · 2026Article
- Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.Nature neuroscience · 2026Article
- Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.bioRxiv : the preprint server for biology · 2026Article
- Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds.PLoS biology · 2025Article
- Powerful and accurate case-control analysis of spatial molecular data.bioRxiv : the preprint server for biology · 2025Article
- Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks.iScience · 2025Article
- The Role of Cognitive Abilities in Project-Based Teaching: A Mixed Methods Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- Brain connectome from neuronal morphology.Network neuroscience (Cambridge, Mass.) · 2025Article
- Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity.Frontiers in synaptic neuroscience · 2025Review
- Age-related changes of node degree in the multiple-demand network predict fluid intelligence.IBRO neuroscience reports · 2024Article
- Review
- Regional brain structure mediates the association between sleep quality and intellectual abilities: the moderating role of socioeconomic status.Brain structure & function · 2024Article
- Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia.Nature neuroscience · 2024Article
- Key morphological features of human pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.Nature communications · 2023Article
- Cortical thickness, gray matter volume, and cognitive performance: a crosssectional study of the moderating effects of age on their interrelationships.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 3 countries.
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Abstract
The left temporal lobe is an integral part of the language system and its cortical structure and function associate with general intelligence. However, whether cortical laminar architecture and cellular properties of this brain area relate to verbal intelligence is unknown. Here, we addressed this using histological analysis and cellular recordings of neurosurgically resected temporal cortex in combination with presurgical IQ scores. We find that subjects with higher general and verbal IQ scores have thicker left (but not right) temporal cortex (Brodmann area 21, BA21). The increased thickness is due to the selective increase in layers 2 and 3 thickness, accompanied by lower neuron densities, and larger dendrites and cell body size of pyramidal neurons in these layers. Furthermore, these neurons sustain faster action potential kinetics, which improves information processing. Our results indicate that verbal mental ability associates with selective adaptations of supragranular layers and their cellular micro-architecture and function in left, but not right temporal cortex.
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