Observational studyeLife2021
A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.
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In one paragraph
Observational study in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Association of Angiotensin Inhibitors with Improved Outcome after Acute Intracerebral Hemorrhage: Secondary Analysis of the INTERACT3 Trial.Cerebrovascular diseases (Basel, Switzerland) · 2026Trial
- Valosin-containing protein, neural proteopathies, and implications for neural regeneration.Neural regeneration research · 2026Article
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- Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG.Molecular psychiatry · 2026Article
- Emergence of Functional Heart-Brain Circuits in a Vertebrate.bioRxiv : the preprint server for biology · 2025Article
- Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia.Research square · 2025Article
- Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons.Scientific reports · 2025Article
- Protocol for image-based small-molecule screen to identify neuroprotective compounds for dopaminergic neurons in zebrafish.STAR protocols · 2024Article
- Article
- Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier.Experimental and therapeutic medicine · 2023Article
- Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish.International journal of molecular sciences · 2023Review
- Mini-Review: Role of Drugs Affecting Renin-Angiotensin System (RAS) in Traumatic Brain Injury (TBI): What We Know and What We Should Know.Korean journal of neurotrauma · 2023Review
- Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders.International journal of molecular sciences · 2023Review
- Insights into Neurodegeneration in Parkinson's Disease from Single-Cell and Spatial Genomics.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- The cell type composition of the adult mouse brain revealed by single cell and spatial genomics.bioRxiv : the preprint server for biology · 2023Article
- Nigral Neurons Degenerating in Parkinson's Disease Express the Angiotensin Receptor Type 1 Gene.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage.Disease models & mechanisms · 2022Article
- Article
- Neuroprotective effect of RAS inhibitors.Nature reviews. Nephrology · 2021Article
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 2 countries.
Gha-Hyun J KimDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-9073-2034
Han MoDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.
Harrison LiuDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
Zhihao WuDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Steven ChenDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
Jiashun ZhengDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Xiang ZhaoDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.
Daryl NucumDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.
James ShortlandDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.
Longping PengDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.
Mannuel ElepanoInstitute for Neurodegenerative Diseases (IND), UCSF Weill Institute forNeurosciences, University of California, San Francisco, San Francisco, United States.
Benjamin TangDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Steven OlsonSmall Molecule Discovery Center, University of California, San Francisco, San Francisco, United States.
Nick ParasInstitute for Neurodegenerative Diseases (IND), UCSF Weill Institute forNeurosciences, University of California, San Francisco, San Francisco, United States.
Hao LiDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Adam R RensloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
Michelle R ArkinDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.
Bo HuangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-1704-4141
Bingwei LuDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, United States.
Su GuoDepartment of Bioengineering and Therapeutic Sciences and Programs in BiologicalSciences and Human Genetics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-7342-0108
University of California, San Francisco · USStanford University · USMcGovern Institute for Brain Research · US
Funding
Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal MaintenanceR01NS084412 · NINDS · STANFORD UNIVERSITY · PI Bingwei Lu · 2014 to 2026
$4.9MGenetic Control of Neural Stem Cell HomeostasisR01NS083417 · NINDS · STANFORD UNIVERSITY · PI LU, BINGWEI · 2013 to 2022
$3.5MCellular Aging and Rejuvenation: A Comprehensive Picture from a Dynamic and Network Perspective - Administrative SupplementR01AG058742 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENNEDY, BRIAN K, LI, HAO · 2018 to 2022
$3.0MPharmaceutical Sciences and PharmacogenomicsT32GM142516 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Su Guo · 2022 to 2026
$2.4MMitochondrial inner membrane architecture in skeletal muscle pathophysiologyR01AR074875 · NIAMS · STANFORD UNIVERSITY · PI LU, BINGWEI · 2019 to 2023
$2.0MMechanisms of renin-angiotensin signaling in programmed and insult-induced neuronal deathR01NS120219 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2021 to 2025
$2.0MReconstructing the Global Epistasis Network for AgingR21AG071899 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, HAO · 2021 to 2022
$444kRejuvenating Aging Human Cells through Transcriptional ReprogrammingR21AG064357 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, HAO · 2020 to 2021
$444kAdvancing Whole-Organism Screening for Chemical Modifiers of the BrainR21NS082938 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., GUO, SU · 2013 to 2014
$410kNIAMS NIH HHS R01 AR074875NIA NIH HHS R01 AG058742NIA NIH HHS R21 AG064357NIA NIH HHS R21 AG071899NIGMS NIH HHS T32 GM142516NINDS NIH HHS R01 NS083417NINDS NIH HHS R01 NS084412NINDS NIH HHS R01 NS120219NINDS NIH HHS R21 NS082938
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we establish a chemogenetic dopamine (DA) neuron ablation model in larval zebrafish with mitochondrial dysfunction and robustness suitable for high-content screening. We use this system to conduct an in vivo DA neuron imaging-based chemical screen and identify the Renin-Angiotensin-Aldosterone System (RAAS) inhibitors as significantly neuroprotective. Knockdown of the angiotensin receptor 1 (
Indexed as
Angiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAnimalsAnimals, Genetically ModifiedAntiparkinson AgentsCase-Control StudiesDatabases, FactualDisease Models, AnimalDopaminergic NeuronsDrosophila melanogasterDrosophila ProteinsGaucher DiseaseHigh-Throughput Screening AssaysHumansMitochondriaNeuroprotective AgentsAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAntiparkinson AgentsDrosophila ProteinsNeuroprotective Agentsp protein, DrosophilaReceptor, Angiotensin, Type 1Zebrafish ProteinsD. melanogasterelectronic health records (EHR)geneticsgenomicsglucocerebrosidase (GBA)humanneurosciencenitroreductase (NTR)-metronidazole (MTZ)parkin, pink1, a-synuclein, dj-1phenotypic screeningtime to Levodopa (L-dopa)zebrafish
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.