Evidence map›Paper›PMID 34550056›Full record

ArticleBeneficial microbes2021

M Engevik, W Ruan, C Visuthranukul, Z Shi, K A Engevik, A C Engevik, R Fultz, D A Schady, J K Spinler, J Versalovic

Open access · bronzeAbstract read
In one paragraph

Article in Beneficial microbes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Endogenous Ethanol Metabolism and Development of MASLD-MASH.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

M EngevikDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
W RuanDepartment of Pediatrics, Baylor College of Medicine, 6701 Fannin Street, Houston, TX 77030, USA.
C VisuthranukulDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Z ShiDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
K A EngevikDepartment of Molecular Virology & Microbiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 7703, USA.
A C EngevikDepartments of Surgery, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA.
R FultzDepartment of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0625, USA.
D A SchadyDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
J K SpinlerDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
J VersalovicDepartment of Pathology & Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
The role of Myosin Vb in Hepatocyte Protein TraffickingK01DK121869 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGEVIK, AMY C · 2019 to 2023
$669k
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
NCI NIH HHS U01 CA170930NIDDK NIH HHS K01 DK121869NIDDK NIH HHS K01 DK123195NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK123704NIDDK NIH HHS T32 DK007664
6 · The paper itself

Abstract

The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. In the absence of SERT, 5-HT remains in the interstitial space and has the potential to aberrantly activate the many 5-HT receptors distributed on the epithelium, immune cells and enteric neurons. Perturbation of SERT is common in many gastrointestinal disorders as well as mouse models of colitis. Select commensal microbes regulate intestinal SERT levels, but the mechanism of this regulation is poorly understood. Additionally, ethanol upregulates SERT in the brain and dendritic cells, but its effects in the intestine have never been examined. We report that the intestinal commensal microbe

Indexed as

ColitisLimosilactobacillus reuteriSerotonin Plasma Membrane Transport ProteinsAnimalsEthanolIntestinal MucosaMiceSerotoninEthanolSerotoninSerotonin Plasma Membrane Transport Proteinslactic acid bacteriaprobioticsserotoninserotonin transporter

Identifiers

PMID34550056
PMCPMC10977654
OpenAlexW3201584244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.