Evidence map›Paper›PMID 34550005›Full record

ArticlemSphere2021

Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes

Natasha L Tilston-Lunel, Stephen R Welch, Sham Nambulli, Rory D de Vries, Gregory W Ho, David E Wentworth, Reed Shabman, Stuart T Nichol, Christina F Spiropoulou, Rik L de Swart and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Canine Distemper Virus Pathogenesis in the Ferret Model.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Natasha L Tilston-LunelCenter for Vaccine Research, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-5290-9350
Stephen R WelchViral Special Pathogens Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.ORCID 0000-0002-6905-8521
Sham NambulliCenter for Vaccine Research, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9781-9703
Rory D de VriesDepartment of Viroscience, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Gregory W HoDepartment of Microbiology, Boston Universitygrid.189504.1 School of Medicine, Boston, Massachusetts, USA.
David E WentworthJ. Craig Venter Institute, Rockville, Maryland, USA.
Reed ShabmanJ. Craig Venter Institute, Rockville, Maryland, USA.
Stuart T NicholViral Special Pathogens Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
Christina F SpiropoulouViral Special Pathogens Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.ORCID 0000-0001-8406-3161
Rik L de SwartDepartment of Viroscience, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-3599-8969
Linda J RennickCenter for Vaccine Research, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5974-6921
W Paul DuprexCenter for Vaccine Research, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1716-6376
Boston University · USCenters for Disease Control and Prevention · USErasmus MC · NLJ. Craig Venter Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defective interfering (DI) genomes restrict viral replication and induce type I interferon. Since DI genomes have been proposed as vaccine adjuvants or therapeutic antiviral agents, it is important to understand their generation, delineate their mechanism of action, develop robust production capacities, assess their safety and

Indexed as

AnimalsCell LineChlorocebus aethiopsDefective VirusesDistemper Virus, CanineDogsFerretsGenome, ViralMaleRaccoonsVero CellsVirus Replicationcanine distemper virusdefective genomesdefective interfering genomesdefective interfering viral particlesferret modelnext-generation sequencingsingle-step attenuationvaccines

Identifiers

PMID34550005
PMCPMC8550193
OpenAlexW3200051684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.