Evidence map›Paper›PMID 34549992›Full record

ArticleMicrobiology spectrum2021

The Mycobacterium tuberculosis sRNA F6 Modifies Expression of Essential Chaperonins, GroEL2 and GroES.

Joanna Houghton, Angela Rodgers, Graham Rose, Alexandre D'Halluin, Terry Kipkorir, Declan Barker, Simon J Waddell, Kristine B Arnvig

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Heliyon · 2023
    Article
  9. Small RNA F6 ProvidesInternational journal of molecular sciences · 2021
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Joanna HoughtonFaculty of Infectious Tropical Diseases, London School of Hygiene and Tropical medicine, London, United Kingdom.
Angela RodgersMycobacterial Metabolism and Antibiotic Research and Host-Pathogen Interactions in Tuberculosis Laboratories, The Francis Crick Institute, London, United Kingdom.
Graham RoseNorth Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children, London, United Kingdom.
Alexandre D'HalluinStructural and Molecular Biology, University College Londongrid.83440.3b, London, United Kingdom.
Terry KipkorirStructural and Molecular Biology, University College Londongrid.83440.3b, London, United Kingdom.
Declan BarkerStructural and Molecular Biology, University College Londongrid.83440.3b, London, United Kingdom.
Simon J WaddellGlobal Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
Kristine B ArnvigStructural and Molecular Biology, University College Londongrid.83440.3b, London, United Kingdom.ORCID 0000-0002-6850-2547
Institute of Structural and Molecular Biology · GBBrighton and Sussex Medical School · GBGreat Ormond Street Hospital · GBLondon School of Hygiene & Tropical Medicine · GBThe Francis Crick Institute · GB

Funding

Medical Research Council MR/L018519/1Medical Research Council MR/S009647/1Medical Research Council U117581288
6 · The paper itself

Abstract

Almost 140 years after the identification of Mycobacterium tuberculosis as the etiological agent of tuberculosis, important aspects of its biology remain poorly described. Little is known about the role of posttranscriptional control of gene expression and RNA biology, including the role of most of the small RNAs (sRNAs) identified to date. We have carried out a detailed investigation of the M. tuberculosis sRNA F6 and shown it to be dependent on SigF for expression and significantly induced in starvation conditions

Indexed as

AnimalsAntigens, BacterialBacterial ProteinsChaperonin 60Disease Models, AnimalGene Expression Regulation, BacterialHeat-Shock ProteinsMiceMice, Inbred BALB CMycobacterium tuberculosisRNA, BacterialRNA, Small UntranslatedSigma FactorStarvationTuberculosisAntigens, BacterialBacterial ProteinsChaperonin 60FliA protein, BacteriagroES protein, Mycobacterium tuberculosisHeat-Shock ProteinsRNA, BacterialRNA, Small UntranslatedSigma Factorhypoxiainfectioninfection modelsmicroarraysMycobacterium tuberculosisnutrient starvationpersistencesmall regulatory RNAsmall RNAWayne model chaperonins

Identifiers

PMID34549992
PMCPMC8557902
OpenAlexW3200518299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.