ArticleJournal of virology2021
Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.
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Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Characterization of full-length and cytoplasmic tail-truncated envelope glycoproteins incorporated into human immunodeficiency virus (HIV-1) virions and virus-like particles.Journal of virology · 2025Article
- Article
- The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs.Communications biology · 2025Article
- Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformation.Journal of virology · 2024Article
- Conformations of membrane human immunodeficiency virus (HIV-1) envelope glycoproteins solubilized in Amphipol A18 lipid-nanodiscs.Journal of virology · 2024Article
- Membrane HIV-1 envelope glycoproteins stabilized more strongly in a pretriggered conformation than natural virus Envs.iScience · 2024Article
- Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells.Journal of virology · 2024Article
- Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.Nature communications · 2023Article
- Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation.Journal of virology · 2023Article
- Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein.PLoS pathogens · 2023Article
- Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles.Journal of virology · 2023Article
- Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.Viruses · 2023Article
- Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles.Communications biology · 2023Article
- Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.Cell chemical biology · 2023Article
- Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles.Journal of virology · 2023Article
- Article
- Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can Be Minimized by Distant State 1-Stabilizing Changes.Journal of virology · 2022Article
- Article
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Authors and funding
13 authors at 7 institutions in 2 countries.
Shijian Zhang *Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kunyu Wang *State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Center for Quantitative Biology, Peking Universitygrid.11135.37, Beijing, China.
Wei Li Wang *Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Hanh T NguyenDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Shuobing ChenState Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Center for Quantitative Biology, Peking Universitygrid.11135.37, Beijing, China.
Maolin LuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-8099-6447
Eden P GoDepartment of Chemistry, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Haitao DingDepartment of Medicine, University of Alabama at Birminghamgrid.265892.2, Alabama, USA.
Robert T SteinbockDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Heather DesaireDepartment of Chemistry, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
John C KappesDepartment of Medicine, University of Alabama at Birminghamgrid.265892.2, Alabama, USA.
Joseph SodroskiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-9750-1615
Youdong MaoDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0001-9302-2257
Harvard University · USIntel (United States) · USPeking University · CNUniversity of Alabama at Birmingham · USUniversity of Kansas · USDana-Farber Cancer Institute · USYale University · US
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2012 to 2018
$204.7MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1MUnderstanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01GM056550 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI HENDRICKSON, WAYNE A. · 1997 to 2018
$31.2MUnderstanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01AI150471 · NIAID · DREXEL UNIVERSITY · PI CHAIKEN, IRWIN M, MOTHES, WALTHER H · 2019 to 2022
$7.8MConformational Landscape of the HIV-1 Envelope GlycoproteinsR01AI124982 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2016 to 2025
$6.7MGenerating Native Env Glycosylation in HIV Vaccine CandidatesR01AI125093 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI DESAIRE, HEATHER R · 2016 to 2019
$2.7MEnrichment of the State-1 Conformation of the HIV-1 Envelope GlycoproteinR01AI145547 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$2.2MSingle-particle Reconstruction of HIV-1 Envelope Glycoprotein TrimersR01AI093256 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2011 to 2015
$2.2MamfAR, The Foundation for AIDS Research (amfAR) 109998-67-RKVAHHS | National Institutes of Health (NIH) AI027767HHS | National Institutes of Health (NIH) AI093256HHS | National Institutes of Health (NIH) AI125093National Natural Science Foundation of China (NSFC) 11774012Natural Science Foundation of Beijing Municipality Z180016/Z18J008NIAID NIH HHS P01 AI150471NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI093256NIAID NIH HHS R01 AI124982NIAID NIH HHS R01 AI125093NIAID NIH HHS R01 AI145547NIAID NIH HHS UM1 AI100645NIGMS NIH HHS P01 GM056550
Abstract
The functional human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer [(gp120/gp41)
Indexed as
AnimalsAntibodies, NeutralizingCHO CellsCricetulusCryoelectron Microscopyenv Gene Products, Human Immunodeficiency VirusHIV-1HIV Envelope Protein gp120HIV Envelope Protein gp41HIV InfectionsHumansProtein BindingProtein ConformationProtein MultimerizationAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV Envelope Protein gp120HIV Envelope Protein gp41antibodyasymmetrycleavageconformationcryo-electron microscopyEnvfurinprocessingstructure
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.