Evidence map›Paper›PMID 34549895›Full record

ArticleMolecular ecology resources2022

Chromosome-scale assembly and whole-genome sequencing of 266 giant panda roundworms provide insights into their evolution, adaptation and potential drug targets.

Lei Han, Tianming Lan, Desheng Li, Haimeng Li, Linhua Deng, Zhiwei Peng, Shaowen He, Yanqiang Zhou, Ruobing Han, Lingling Li and 18 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular ecology resources, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 9 institutions in 2 countries.

Lei HanCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Tianming LanState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, China.
Desheng LiKey Laboratory of SFGA on Conservation Biology of Rare Animals in the Giant Panda National Park (CCRCGP), Sichuan, China.
Haimeng LiState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, China.
Linhua DengKey Laboratory of SFGA on Conservation Biology of Rare Animals in the Giant Panda National Park (CCRCGP), Sichuan, China.
Zhiwei PengCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Shaowen HeFoping National Nature Reserve, Hanzhong, China.
Yanqiang ZhouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Ruobing HanCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Lingling LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yaxian LuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Haorong LuGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, China.
Qing WangBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Shangchen YangCollege of Life Sciences, Zhejiang University, Hangzhou, China.
Yixin ZhuBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Yunting HuangGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, China.
Xiaofang ChengMGI, BGI-Shenzhen, Shenzhen, China.
Jieyao YuGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, China.
Yulong WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Heting SunGeneral Station for Surveillance of Wildlife Diseases, National Forestry and Grassland Administration, Harbin, China.
Hongliang ChaiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Huanming YangState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, China.
Xun XuState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, China.
Michael LisbyLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Quan LiuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Karsten KristiansenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Huan LiuState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, China.
Zhijun HouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.ORCID https://orcid.org/0000-0002-8704-1651
BGI Group (China) · CNNortheast Forestry University · CNState Forestry and Grassland Administration · CNChengdu Research Base of Giant Panda Breeding · CNUniversity of Chinese Academy of Sciences · CNUniversity of Copenhagen · DKFanjingshan National Nature Reserve · CNFoshan University · CNZhejiang University · CN

Funding

Forestry science and technology research project 20180302Fundamental Research Funds for the Central Universities of China 2572020AA30National Key R&D Program 2017YFD0501702Open Project of Key Laboratory of SFGA on Conservation Biology of Rare Animals in The Giant Panda National Park 2020004The Foundation of Key Laboratory of State Forestry and Grassland Administration (State Park Administration) on Conservation Biology of Rare Animals in the Giant Panda National Park KLSFGAGP2020.002The Guangdong Provincial Key Laboratory of Genome Read and Write 2017B030301011The Pearl River Talent Recruitment Program in Guangdong Province 2019CX01N111
6 · The paper itself

Abstract

Helminth diseases have long been a threat to the health of humans and animals. Roundworms are important organisms for studying parasitic mechanisms, disease transmission and prevention. The study of parasites in the giant panda is of importance for understanding how roundworms adapt to the host. Here, we report a high-quality chromosome-scale genome of Baylisascaris schroederi with a genome size of 253.60 Mb and 19,262 predicted protein-coding genes. We found that gene families related to epidermal chitin synthesis and environmental information processes in the roundworm genome have expanded significantly. Furthermore, we demonstrated unique genes involved in essential amino acid metabolism in the B. schroederi genome, inferred to be essential for the adaptation to the giant panda-specific diet. In addition, under different deworming pressures, we found that four resistance-related genes (glc-1, nrf-6, bre-4 and ced-7) were under strong positive selection in a captive population. Finally, 23 known drug targets and 47 potential drug target proteins were identified. The genome provides a unique reference for inferring the early evolution of roundworms and their adaptation to the host. Population genetic analysis and drug sensitivity prediction provide insights revealing the impact of deworming history on population genetic structure of importance for disease prevention.

Indexed as

AscaridoideaPharmaceutical PreparationsUrsidaeAnimalsChromosomesHumansPharmaceutical PreparationsadaptationanthelminticsBaylisascaris schroederigenetic diversityroundworms

Identifiers

PMID34549895
PMCPMC9298223
OpenAlexW3156712118

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.