ArticleJournal of sleep research2022
Sleep and perivascular spaces in the middle-aged and elderly population.
Article in Journal of sleep research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study.Sleep medicine · 2025Article
- The causal relationship between enlarged perivascular spaces and intracerebral hemorrhage: A 2-sample Mendelian randomization study.Medicine · 2025Article
- The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults.Frontiers in aging neuroscience · 2025Article
- Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct.Journal of cardiovascular development and disease · 2024Article
- Association of objective sleep duration with cognition and brain aging biomarkers in older adults.Brain communications · 2024Article
- Effects of sleep on brain perivascular space in a cognitively healthy population.Sleep medicine · 2023Article
- Sleep and Perivascular Spaces.Current neurology and neuroscience reports · 2023Review
- Arterial spin labeling signal in the CSF: Implications for partial volume correction and blood-CSF barrier characterization.NMR in biomedicine · 2023Article
- Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals.Sleep medicine · 2022Article
- Prevalence and Risk Factors for Enlarged Perivascular Spaces in Young Adults from a Neurology Clinic-Based Cohort.Brain sciences · 2022Article
- Sleep and perivascular spaces in the middle-aged and elderly population.Journal of sleep research · 2022Article
- Perivascular spaces visible on magnetic resonance imaging predict subsequent delirium in older patients.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep has been hypothesised to facilitate waste clearance from the brain. We aimed to determine whether sleep is associated with perivascular spaces on brain magnetic resonance imaging (MRI), a potential marker of impaired brain waste clearance, in a population-based cohort of middle-aged and elderly people. In 559 participants (mean [SD] age 62 [6] years, 52% women) from the population-based Rotterdam Study, we measured total sleep time, sleep onset latency, wake after sleep onset and sleep efficiency with actigraphy and polysomnography. Perivascular space load was determined with brain MRI in four regions (centrum semiovale, basal ganglia, hippocampus, and midbrain) via a validated machine learning algorithm using T2-weighted MR images. Associations between sleep characteristics and perivascular space load were analysed with zero-inflated negative binomial regression models adjusted for various confounders. We found that higher actigraphy-estimated sleep efficiency was associated with a higher perivascular space load in the centrum semiovale (odds ratio 1.10, 95% confidence interval 1.04-1.16, p = 0.0008). No other actigraphic or polysomnographic sleep characteristics were associated with perivascular space load in other brain regions. We conclude that, contrary to our hypothesis, associations of sleep with perivascular space load in this middle-aged and elderly population remained limited to an association of a high actigraphy-estimated sleep efficiency with a higher perivascular space load in the centrum semiovale.
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