ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Electrospun PLGA scaffold loaded with osteogenic growth peptide accelerates cranial bone repair in rats].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Strategies for Craniofacial Tissue Engineering: Innovations for Scalable Bone Regeneration.Plastic and aesthetic research · 2025Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the feasibility of electrospun poly(D, L-lactide-co-glycolide) (PLGA) scaffold loaded with osteogenic growth peptide (OGP) for bone tissue engineering.
methodsPLGA scaffolds were prepared by electrospinning PLGA solution without OGP(control group)or with 0.1%, 0.2%and 0.4%OGP(0.1%OGP@PLGA, 0.2%OGP@PLGA, and 0.4%OGP@PLGA scaffolds, respectively).The microstructure of the scaffolds was observed by scanning electron microscopy(SEM).The scaffolds were soaked in PBS to confirm the release pattern of OGP.The biocompatibility of the scaffolds was evaluated using CCK-8 assay and live/dead staining after a 7-day coculture with rat bone marrow-derived mesenchymal stem cells(BMSCs).ALP assay and ARS staining were used to evaluate osteoinduction capacity of the scaffolds co-cultured with rat BMSCs for 14 days.In a male SD rat model of skull defect(5 mm in diameter), bone defect repair was evaluated 8 weeks after implantation of the scaffolds using Micro-CT, HE and Masson staining.
resultsThe electrospun scaffolds had a fibrous structure similar to extracellular matrix(ECM)and were capable of sustained release of OGP for at least one month.Co-culture with 0.2%OGP@PLGA and 0.4%OGP@PLGA scaffolds, as compared with pure PLGA scaffold, significantly promoted the growth of rat BMSCs ((
conclusionThe electrospun PLGA scaffold loaded with OGP effectively mimics the structure of ECM and has a good biocompatibility and osteoinduction ability, suggesting its potential as a new bone tissue engineering scaffold for bone defect repair.
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