ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Bax inhibitor-1 inhibits calcification of vascular smooth muscle cells
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of Bax inhibitor-1(BI-1)on calcification of vascular smooth muscle cells(VSMCs).
methodsVSMCs were isolated from the thoracic aorta of SD rats.VSMCs or BI-1-overexpressing VSMCs(transfected with a BI-1-overexpressing plasmid) were cultured in normal medium or calcified medium containing β-glycerophosphate and calcium chloride, and the cell calcification was examined with Alizarin red staining.Enzyme-linked immunosorbent assay was used to determine the intracellular calcium content and alkaline phosphatase activity.The expression levels of Runt-related transcription factor 2 (RUNX2), bone morphogenetic protein 2 (BMP-2) and caspase-3 were detected with Western blotting.
resultsAfter 14 days of culture in the calcified medium, the VSMCs showed significantly reduced expression of BI-1 protein(
conclusionBI-1 may attenuate vascular calcification by inhibiting calcium deposition, osteogenic differentiation and apoptosis.
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