ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Down-regulation of neuregulin2 (NRG2) following spinal cord injury in C57BL/6 mice: Its implications in therapeutic potential.Iranian journal of basic medical sciences · 2025Article
- Discovery of novel targets and mechanisms of MEK inhibitor Selumetinib for LGG treatment based on molecular docking and molecular dynamics simulation.Journal of molecular modeling · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveTo investigate neuregulin 2 (NRG2) expression in gliomas and its role in glioma development.
methodsWe compared the expression levels of NRG2 and glial fibrillary acidic protein (GFAP) in low-grade glioma (LGG) and glioblastoma multiforme (GBM) with those in normal control samples using GEPIA database.The correlation between NRG2 and GFAP expression and their association with the overall survival of patients with LGG and GBM were analyzed.Immunohistochemical staining was used to detect NRG2 protein expression levels in a tissue microarray consisting of human gliomas of different grades, and potential co-localization of NRG2 and GFAP was analyzed using a double-labeling immunofluorescence assay.Western blotting was used to investigate the effect of perifosine (an AKT inhibitor) on the regulation of GFAP expression by NRG2 in human glioblastoma U-87 MG cells.
resultsBoth LGG and GBM tissues, especially the former, exhibited high expressions of NRG2 (
conclusionNRG2 is highly expressed in gliomas of different grades and regulates GFAP expression in glioma cells at least partly
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