ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Melatonin alleviates myocardial ischemia-reperfusion injury in mice by inhibiting inflammatory response
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Vitamin C Inhibits Scale Drop Disease Virus Infectivity by Targeting Nrf2 to Reduce Ferroptosis.Antioxidants (Basel, Switzerland) · 2025Article
- [Hyperoside protects mouse spermatocytes GC-2 cells from oxidative damage by activating the Keap1/Nrf2/HO-1 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the protective effect of melatonin against myocardial ischemia-reperfusion (IR) injury in mice and the role of Nrf2 signaling in mediating this effect.
methodsC57/bl6 mice were randomized into sham-operated group(Sham), IR group(IR), IR with melatonin treatment(melatonin+IR)group, and IR with melatonin and Nrf2 inhibitor ML-385 (melatonin+ML-385+IR) group.In the latter 3 groups, mouse models of myocardial IR injury were established by ligation of the left anterior descending coronary artery.The infarct size was measured with Evans blue/TTC staining, and serum LDH level was detected using ELISA.The ejection fraction (EF) and fractional shortening (FS) of the mice were measured using Vevo software.The expressions of Bcl2, Bax, Nrf2, Nrf2 substrates NQO-1 and HO-1, TNF-α, IL-1β, and IL-6 in the myocardial tissues were detected with Western blotting.
resultsCompared with the sham-operated mice, the mouse models of myocardial IR injury showed significantly increased infarct size and serum LDH levels (
conclusionMelatonin can alleviate myocardial IR injury in mice by inhibiting inflammatory response
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.