ArticleEndocrine2022
Quantitative T1 mapping MRI for the assessment of extraocular muscle fibrosis in thyroid-associated ophthalmopathy.
Article in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Current insights of applying MRI in Graves' ophthalmopathy.Frontiers in endocrinology · 2022Pooled it
- Quantitative Multi-Parameter MRI Evaluation of Hashimoto's Thyroiditis Changes After Dietary Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Comparative evaluation of MRI Dixon T2-weighted, T2 mapping, and T1 mapping for Graves' ophthalmopathy activity assessment.Eye (London, England) · 2026Article
- Liver findings in newly diagnosed, treatment-naive patients with Crohn's disease: a preliminary study of MRI proton density fat fraction and extracellular volume fraction.BMC medical imaging · 2026Article
- Added value of multiparametric MRI combining dynamic contrast-enhanced and diffusion-weighted imaging for determining thyroid-associated ophthalmopathy activity.European radiology · 2026Article
- Multiparametric MRI quantitative metrics for grading and staging graves' ophthalmopathy.BMC medical imaging · 2026Article
- Reliability of extraocular muscle biomechanics in the evaluation of disease activity in thyroid eye disease.Journal of endocrinological investigation · 2026Article
- Habitat imaging based on water-fat separation for interpreting extraocular muscle heterogeneity in thyroid eye disease.European thyroid journal · 2026Article
- Scan-rescan reproducibility and interobserver reliability of T1 and T2 measurements of extraocular muscles using a multi-dynamic multi-echo MRI sequence.BMC medical imaging · 2026Article
- Quantitative Chemical Exchange Saturation Transfer MRI for Diagnosing Thyroid-Associated Ophthalmopathy Activity: A Prospective Feasibility Study.Korean journal of radiology · 2026Article
- Selective extraocular muscle regression following tocilizumab in active thyroid associated ophthalmopathy: a 3D MRI-based retrospective study.Frontiers in endocrinology · 2026Article
- Teprotumumab N01 for thyroid eye disease in China: clinical outcomes and quantitative MRI correlations.Frontiers in medicine · 2026Article
- Rapid multiparametric quantitative MRI for predicting the activity of thyroid-associated ophthalmopathy: combination with clinical characteristics.European radiology · 2025Article
- Quadrant asymmetry alteration of retinal degeneration in thyroid-associated ophthalmopathy.Journal of translational medicine · 2025Article
- The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy.Diagnostics (Basel, Switzerland) · 2025Review
- Fat-suppression T2 relaxation time and water fraction predict response to intravenous glucocorticoid therapy for thyroid-associated ophthalmopathy.European radiology · 2025Article
- Evaluation of Inflammatory Activity of Extraocular Muscles in Thyroid Associated Orbitopathy by [Molecular imaging and biology · 2025Article
- MRI-based SIR quantitative biomarkers: a novel imaging diagnostic strategy for thyroid eye disease activity staging.Frontiers in endocrinology · 2025Article
- Application progress of magnetic resonance imaging in thyroid associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Advancements in imaging research in thyroid-associated ophthalmopathy.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe aimed to investigate the performance of T1 mapping and its histological correlation with extraocular muscle fibrosis in thyroid-associated ophthalmopathy (TAO).
methodsWe prospectively recruited 12 cases of active TAO, 12 cases of inactive TAO, and 15 cases of control subjects. All participants underwent magnetic resonance imaging (MRI) scan with pre-/postcontrast T1 mapping and short-time inversion-recovery (STIR) sequence. The images were analyzed to obtain precontrast T1, extracellular-volume (ECV) fraction on T1 mapping, and signal-intensity ratio (SIR) on STIR for each rectus. Muscle biopsy was performed at lateral rectus to quantify-collagen volume fraction, glycosaminoglycan (GAG)-volume fraction, and extracellular space component. The relationship between MRI and histopathology was examined with Pearson correlation coefficient.
resultsThe active TAO group was characterized with GAG accumulation, while the inactive TAO group presented with substantial fibrosis. The MRI parameters achieved acceptable interobserver and intraobserver agreement. The precontrast T1 and ECV remarkably increased in the TAO groups than the control group, and ECV positively correlated with collagen-volume fraction (r = 0.913) and extracellular-space component (r = 0.886) in the inactive TAO group. The SIR statistically increased in the active TAO group, and SIR positively correlated with GAG-volume fraction in all three groups. The performance of ECV (cutoff > 48.1%) to screen out extraocular muscle fibrosis in inactive TAO was 60.9% sensitivity and 93.3% specificity.
conclusionsThe ECV parameter on T1 mapping MRI is a reliable tool to quantify extraocular muscle fibrosis, providing insights into noninvasive evaluation of pathological changes in TAO orbit. TRIAL REGISTRATION NUMBER: ChiCTR2000040394; Date of registration: 28 November 2020.
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