Evidence map›Paper›PMID 34549356›Full record

ArticleIntensive care medicine experimental2021

A randomised controlled trial of succinylated gelatin (4%) fluid on urinary acute kidney injury biomarkers in cardiac surgical patients.

Lisa Smart, Corrin Boyd, Edward Litton, Warren Pavey, Philip Vlaskovsky, Umar Ali, Trevor Mori, Anne Barden, Kwok Ming Ho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lisa SmartCollege of Science, Health, Engineering and Education, Murdoch University, South St, Murdoch, WA, 6150, Australia. l.smart@murdoch.edu.au.ORCID http://orcid.org/0000-0003-4776-2849
Corrin BoydCollege of Science, Health, Engineering and Education, Murdoch University, South St, Murdoch, WA, 6150, Australia.
Edward LittonIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Australia.
Warren PaveyCollege of Science, Health, Engineering and Education, Murdoch University, South St, Murdoch, WA, 6150, Australia.
Philip VlaskovskyMedical School, University of Western Australia, Perth, Australia.
Umar AliDepartment of Cardiothoracic Surgery and Transplantation, Fiona Stanley Hospital, Murdoch, Australia.
Trevor MoriMedical School, University of Western Australia, Perth, Australia.
Anne BardenMedical School, University of Western Australia, Perth, Australia.
Kwok Ming HoCollege of Science, Health, Engineering and Education, Murdoch University, South St, Murdoch, WA, 6150, Australia.
Murdoch University · AUThe University of Western Australia · AUFiona Stanley Hospital · AUSt John of God Subiaco Hospital · AU

Funding

Royal Perth Hospital Medical Research Foundation MRF 2017-32
6 · The paper itself

Abstract

backgroundFluid resuscitation is frequently required for cardiac surgical patients admitted to the intensive care unit. The ideal fluid of choice in regard to efficacy and safety remains uncertain. Compared with crystalloid fluid, colloid fluid may result in less positive fluid balance. However, some synthetic colloids are associated with increased risk of acute kidney injury (AKI). This study compared the effects of succinylated gelatin (4%) (GEL) with compound sodium lactate (CSL) on urinary AKI biomarkers in patients after cardiac surgery.

methodsCardiac surgical patients who required an intravenous fluid bolus of at least 500 mL postoperatively were randomly allocated to receive GEL or CSL as the resuscitation fluid of choice for the subsequent 24 h. Primary outcomes were serial urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C concentrations measured at baseline, 1 h, 5 h and 24 h after enrolment, with higher concentrations indicating greater kidney injury. Secondary biomarker outcomes included urinary clusterin, α1-microglobulin and F

resultsForty cardiac surgical patients (n = 20 per group) with similar baseline characteristics were included. There was no significant difference in the median volume of fluid boluses administered over 24 h between the GEL (1250 mL, Q1-Q3 500-1750) and CSL group (1000 mL, Q1-Q3 500-1375) (P = 0.42). There was a significantly greater increase in urinary cystatin C (P < 0.001), clusterin (P < 0.001), α1-microglobulin (P < 0.001) and F

conclusionsThis preliminary randomised controlled trial showed that use of succinylated gelatin (4%) for fluid resuscitation after cardiac surgery was associated with increased biomarker concentrations of renal tubular injury and dysfunction, compared to crystalloid fluid. These results generate concern that use of intravenous gelatin fluid may contribute to clinically relevant postoperative AKI. Trial registration ANZCTR.org.au, ACTRN12617001461381. Registered on 16th October, 2017, http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373619&isReview=true .

Indexed as

Cardiac surgeryColloidFluid resuscitationRenalUrine

Identifiers

PMID34549356
PMCPMC8455786
OpenAlexW3201583012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.