Evidence map›Paper›PMID 34549323›Full record

ArticleAnalytical and bioanalytical chemistry2021

Untargeted and targeted analysis of sarin poisoning biomarkers in rat urine by liquid chromatography and tandem mass spectrometry.

M F Vokuev, Т М Baygildiev, I V Plyushchenko, Y A Ikhalaynen, R L Ogorodnikov, I K Solontsov, А V Braun, E I Savelieva, I V Rуbalchenko, I A Rodin

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Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M F Vokuev *Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia. vokuevmihail11@gmail.com.
Т М Baygildiev *Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
I V Plyushchenko *Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Y A IkhalaynenDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
R L OgorodnikovDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
I K SolontsovDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
А V BraunDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
E I SavelievaResearch Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency of Russia, Kuz'molovsky g/p, 188663, Leningrad Region, Russia.
I V RуbalchenkoDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
I A RodinDepartment of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Lomonosov Moscow State University · RUFederal Medical-Biological Agency · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical warfare agents continue to pose a real threat to humanity, despite their prohibition under the Chemical Weapons Convention. Sarin is one of the most toxic and lethal representatives of nerve agents. The methodology for the targeted analysis of known sarin metabolites has reached great heights, but little attention has been paid to the untargeted analysis of biological samples of victims exposed to this deadly poisonous substance. At present, the development of computational and statistical methods of analysis offers great opportunities for finding new metabolites or understanding the mechanisms of action or effect of toxic substances on the organism. This study presents the targeted LC-MS/MS determination of methylphosphonic acid and isopropyl methylphosphonic acid in the urine of rats exposed to a non-lethal dose of sarin, as well as the untarget urine analysis by LC-HRMS. Targeted analysis of polar acidic sarin metabolites was performed on a mixed-mode reversed-phase anion-exchange column, and untargeted analysis on a conventional reversed-phase C18 column. Isopropyl methylphosphonic acid was detected and quantified within 5 days after subcutaneous injection of sarin at a dose of 1/4 LD

Indexed as

AnimalsBiomarkersChemical Warfare AgentsChromatography, LiquidLimit of DetectionMaleMetabolomicsRatsReference StandardsReproducibility of ResultsSarinTandem Mass SpectrometryBiomarkersChemical Warfare AgentsSarinChemical warfare agentsMetabolomicsSarinTargeted analysisUntargeted analysisUrinary metabolites

Identifiers

PMID34549323
OpenAlexW3200625471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.