Evidence map›Paper›PMID 34549316›Full record

ArticlePsychopharmacology2022

Chemogenetic modulation reveals distinct roles of the subthalamic nucleus and its afferents in the regulation of locomotor sensitization to amphetamine in rats.

K G Nakata, E Yin, E Sutlief, Susan M Ferguson

Abstract read
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In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

K G NakataGraduate Program in Neuroscience, University of Washington, Seattle, WA, 98195, USA.
E YinCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
E SutliefCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Susan M FergusonGraduate Program in Neuroscience, University of Washington, Seattle, WA, 98195, USA. smfergus@uw.edu.

Funding

Role of specific cortico-basal ganglia pathways in animal models of addictionR01DA036582 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI FERGUSON, SUSAN MARIE · 2014 to 2018
$2.3M
NIDA NIH HHS R01DA036582
6 · The paper itself

Abstract

The subthalamic nucleus (STN) is a key node in cortico-basal-ganglia thalamic circuits, guiding behavioral output through its position as an excitatory relay of the striatal indirect pathway and its direct connections with the cortex. There have been conflicting results regarding the role of the STN in addiction-related behavior to psychostimulants, and little is known with respect to the role of STN afferents. To address this, we used viral vectors to express DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) in the STN of rats in order to bidirectionally manipulate STN activity during the induction of amphetamine sensitization. In addition, we used a Cre-recombinase dependent G

Indexed as

Basal ForebrainCentral Nervous System StimulantsSubthalamic NucleusAmphetamineAnimalsNeural PathwaysRatsThalamusAmphetamineCentral Nervous System StimulantsAmphetamineChemogeneticsRatsSubthalamic nucleus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.