ArticleAnnals of botany2022
Cytosolic phosphofructokinases are important for sugar homeostasis in leaves of Arabidopsis thaliana.
Article in Annals of botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 21 citations in OpenAlex.
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- Genome-wide-association-analysis-based identification of genetic loci and candidate genes associated with seedling emergence rate in super-sweet corn (Zea mays L.).BMC plant biology · 2026Article
- The grape berry methylome reveals tissue-specific features associated with metabolism in ripening.Horticulture research · 2025Article
- Transcriptomic insights into gibberellin-3-mediated regulation of bud dormancy and metabolic transition in pitaya (Hylocereus polyrhizus).Plant cell reports · 2025Article
- Genome-Wide Association Study and Candidate Gene Identification for Girth Traits in Rubber Tree.Plants (Basel, Switzerland) · 2025Article
- Genome-wide identification of the phosphofructokinase gene family in maize (Zea mays L.) and their expression levels under abiotic stress and phytohormones.BMC plant biology · 2025Article
- Transcriptome Analysis Reveals Sugar and Hormone Signaling Pathways Mediating Flower Induction in Pitaya (International journal of molecular sciences · 2025Article
- Mild Intermittent Cold Stimulation Affects Cardiac Substance Metabolism via the Neuroendocrine Pathway in Broilers.Animals : an open access journal from MDPI · 2023Article
- The Arabidopsis thaliana METACASPASE IIf Regulates Sugar Metabolism and Delays Dark-Induced Leaf Senescence.Physiologia plantarumArticle
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Authors and funding
11 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsATP-dependent phosphofructokinases (PFKs) catalyse phosphorylation of the carbon-1 position of fructose-6-phosphate, to form fructose-1,6-bisphosphate. In the cytosol, this is considered a key step in channelling carbon into glycolysis. Arabidopsis thaliana has seven genes encoding PFK isoforms, two chloroplastic and five cytosolic. This study focuses on the four major cytosolic isoforms of PFK in vegetative tissues of A. thaliana.
methodsWe isolated homozygous knockout individual mutants (pfk1, pfk3, pfk6 and pfk7) and two double mutants (pfk1/7 and pfk3/6), and characterized their growth and metabolic phenotypes. KEY
resultsIn contrast to single mutants and the double mutant pfk3/6 for the hypoxia-responsive isoforms, the double mutant pfk1/7 had reduced PFK activity and showed a clear visual and metabolic phenotype with reduced shoot growth, early flowering and elevated hexose levels. This mutant also has an altered ratio of short/long aliphatic glucosinolates and an altered root-shoot distribution. Surprisingly, this mutant does not show any major changes in short-term carbon flux and in levels of hexose-phosphates.
conclusionsWe conclude that the two isoforms PFK1 and PFK7 are important for sugar homeostasis in leaf metabolism and apparently in source-sink relationships in A. thaliana, while PFK3 and PFK6 only play a minor role under normal growth conditions.
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