Evidence map›Paper›PMID 34549191›Full record

ArticleCritical care explorations2021

Clusters Across Multiple Domains of Health-Related Quality of Life Reveal Complex Patient Outcomes After Subarachnoid Hemorrhage.

Julianne Murphy, Hye Jung Shin, Hanyin Wang, Yuan Luo, Babak Jahromi, Thomas P Bleck, David Cella, Andrew M Naidech

Abstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Timing of neuroprognostication in the ICU.Current opinion in critical care · 2025
    Review
  2. Article
  3. Big Data in Stroke: How to Use Big Data to Make the Next Management Decision.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julianne MurphyCenter for Education in Health Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Hye Jung ShinInstitute for Public Health and Medicine, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Hanyin WangDepartment of Preventive Medicine, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Yuan LuoDepartment of Preventive Medicine, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Babak JahromiDepartment of Neurological Surgery, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Thomas P BleckDepartment of Neurology, Feinberg School of Medicine of Northwestern University, Chicago, IL.
David CellaDepartment of Medical Social Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL.
Andrew M NaidechInstitute for Public Health and Medicine, Feinberg School of Medicine of Northwestern University, Chicago, IL.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Making Acute Stroke Trials Succeed: Challenges and Potential SolutionsU01NS110772 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Jordan J. Elm · 2020 to 2026
$24.3M
National Infrastructure for Standardized and Portable EHR Phenotyping AlgorithmsR01GM105688 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LUO, YUAN, PATHAK, JYOTISHMAN · 2013 to 2020
$5.7M
Hemostasis, Hematoma Expansion, and Outcomes After Intracerebral HemorrhageR01NS110779 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAIDECH, ANDREW M · 2019 to 2023
$3.3M
Modeling the Incompleteness and Biases of Health DataR01LM013337 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, YUAN · 2020 to 2023
$1.3M
Predoctoral Training Program in Biomedical Data Driven Discovery (BD3)T32LM012203 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLABJAN, DIEGO, STARREN, JUSTIN B. · 2015 to 2019
$1.1M
NCATS NIH HHS UL1 TR001422NIGMS NIH HHS R01 GM105688NINDS NIH HHS R01 NS110779NINDS NIH HHS U01 NS110772NLM NIH HHS R01 LM013337NLM NIH HHS T32 LM012203
6 · The paper itself

Abstract

Patients with aneurysmal subarachnoid hemorrhage (ruptured brain aneurysm) often have reduced health-related quality of life at follow-up in multiple domains (e.g., cognitive function and social function). We tested the hypothesis that there are distinct patterns of patient outcomes across domains of health-related quality of life, "complex patient outcomes," in survivors of subarachnoid hemorrhage.

designPatients with subarachnoid hemorrhage were prospectively identified. Clinical data were prospectively recorded. Health-related quality of life was prospectively assessed at 3-month follow-up using the National Institutes of Health Patient Reported Outcomes Measurement Information System and neuro-quality of life in the domains of mobility, cognitive function, satisfaction with social roles, and depression. We used k-means clustering to analyze prospectively recorded health-related quality of life data, identifying clusters of complex patient outcomes. Decision tree analysis identified index hospital stay factors predictive of a patient having a particular complex patient outcome at follow-up.

settingAcademic medical center. PATIENTS: One hundred three survivors of subarachnoid hemorrhage.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe analyzed 103 patients, of whom 75 (72.8%) were female, and mean age was 53.6 ± 13.4 years. There were three complex patient outcomes: health-related quality of life greater than 1 sd better than the U.S. mean across all domains (

conclusionsComplex patient outcomes across multiple domains of health-related quality of life at follow-up after subarachnoid hemorrhage are distinct and may be predictable.

Indexed as

outcomes researchquality of lifesubarachnoid hemorrhage

Identifiers

PMID34549191
PMCPMC8443826

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.