ArticleBrain hemorrhages2021
Symptomatic peduncular, cavernous bleeding following SARS-CoV-2 vaccination induced immune thrombocytopenia.
Article in Brain hemorrhages, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Special considerations and pitfalls for intracerebral bleeding followed COVID-19 case treated by ECMO.Brain hemorrhages · 2023Article
- A review of neurological side effects of COVID-19 vaccination.European journal of medical research · 2023Review
- Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review.Journal of autoimmunity · 2022Review
- Spinal intramedullary cavernous angioma patient in a pain clinic - A case report.Anesthesia and pain medicine · 2022Article
- Attribute fatal, multiple cavitary lesions with air-fluid levels and hemorraghe to SARS-CoV-2 or ECMO only after ruling out differentials.Brain hemorrhages · 2022Article
- Thrombosis post-mRNA-based SARS-CoV-2 vaccination (BNT162b2) - Time to think beyond thrombosis with thrombocytopenia syndrome (TTS).Thrombosis update · 2022Article
- The etiology of SARS-CoV-.2 associated intra-cranial hemorrhage is broad.Brain hemorrhages · 2022Article
- Lobar bleeding with ventricular rupture shortly after first dosage of an mRNA-based SARS-CoV-2 vaccine.Brain hemorrhages · 2022Article
- Neurological side effects of SARS-CoV-2 vaccinations.Acta neurologica Scandinavica · 2022Review
- Special issue Editorial: Neurologic manifestations of the Covid-19 pandemic.Brain hemorrhages · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapy-responsive immune thrombocytopenia and anemia shortly after the second dose of an mRNA-based SARS-CoV-2 vaccine, which was complicated by symptomatic bleeding within a pre-existing brainstem cavernoma, has not been reported. The patient is a 68yo male who experienced gait disturbance and hypoesthesia of the left face and left upper extremity two days after the second dose of the mRNA-based SARS-CoV-2 vaccine BNT162b2 (Tozinameran). Clinical neurologic exam revealed hypoesthesia of the left face and the left upper extremity and ataxic gait. Blood tests revealed macrocytic anemia and marked thrombocytopenia, interpreted as vaccination induced immune thrombocytopenia (ITP). Cerebral MRI revealed subacute bleeding within a pre-existing solitary cavernoma located in the right cerebellar peduncle. With proceeding resorption of the bleeding, symptoms gradually regressed. This case shows that SARS-CoV-2 vaccinations may be followed by ITP and bleeding in pre-existing vascular malformations. In order to avoid cavernoma bleeding in patients with SARS-CoV-2 vaccination associated ITP and thrombocyte dysfunction, urgent treatment of ITP is warranted. In order to identify patients at risk for experiencing SARS-CoV-2 vaccination induced ITP, further studies are urgently warranted.
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