Evidence map›Paper›PMID 34549102›Full record

ArticleACS omega2021

NAChRDB: A Web Resource of Structure-Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors.

Aliaksei Chareshneu, Purbaj Pant, Ravi José Tristão Ramos, David Sehnal, Tuğrul Gökbel, Crina-Maria Ionescu, Jaroslav Koča

Abstract read
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aliaksei ChareshneuCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.ORCID https://orcid.org/0000-0002-4323-2130
Purbaj PantCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.
Ravi José Tristão RamosCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.
David SehnalCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.
Tuğrul GökbelDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, İzmir 35430, Turkey.
Crina-Maria IonescuCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.
Jaroslav KočaCEITEC - Central European Institute of Technology, Masaryk University, Brno 601 77, Czech Republic.ORCID https://orcid.org/0000-0002-2780-4901

Funding

Wellcome Trust 104948
6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) comprise a large and ancient family of allosteric ion channels mediating synaptic transmission. The vast knowledge about nAChRs has become difficult to navigate. NAChRDB is a web-accessible resource of curated residue-level functional annotations of neuromuscular nAChRs. Interactive three-dimensional (3D) visualization and sequence alignment give further context to this rich and growing collection of experimental observations and computational predictions. NAChRDB is freely available at https://crocodile.ncbr.muni.cz/Apps/NAChRDB/, with interactive tutorials and regular updates to the content and web interface. No installation or user registration is required. NAChRDB is accessible through any modern internet browser on desktops and mobile devices. By providing immediate and systematic access to practical knowledge gained through decades of research, NAChRDB represents a powerful educational tool and helps guide discovery by revealing gaps in current knowledge and aiding the interpretation of results of molecular and structural biology experiments or computational studies.

Identifiers

PMID34549102
PMCPMC8444218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.