Evidence map›Paper›PMID 34549083›Full record

ArticleTransplantation direct2021

Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Haley P Hostetler, Megan L Neely, Francine L Kelly, John A Belperio, Marie Budev, John M Reynolds, Pali D Shah, Lianne G Singer, Laurie D Snyder, Scott M Palmer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Haley P HostetlerDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
Megan L NeelyDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC.
Francine L KellyDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
John A BelperioDepartment of Medicine, University of California Los Angeles, Los Angeles, CA.
Marie BudevDepartment of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH.
John M ReynoldsDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
Pali D ShahDepartment of Medicine, Johns Hopkins University, Baltimore, MD.
Lianne G SingerDepartment of Medicine, Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Laurie D SnyderDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
Scott M PalmerDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
Jamie L ToddDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.
Clinical Research Institute · USDuke Medical Center · USCleveland Clinic · USJohns Hopkins University · USUniversity of California, Los Angeles · US

Funding

The Lung Transplant Clinical Trials Network (LT-CTN)U01AI113315 · NIAID · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2014 to 2018
$12.9M
NIAID NIH HHS U01 AI113315
6 · The paper itself

Abstract

backgroundAcute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate immune agonist, breaking tolerance and potentiating alloimmunity. We previously demonstrated HA accumulates in CLAD after human-lung transplantation. We sought to determine if HA accumulates in the bronchoalveolar lavage fluid (BALF) concurrent with AR in lung recipients.

methodsThe cohort consisted of 126 first adult lung recipients at 5 transplant centers with a total of 373 BALF samples collected within the first posttransplant year. All samples were paired with a lung biopsy from the same bronchoscopy. BALF HA (ng/mL) was quantified by ELISA and log-transformed for analysis. Linear-mixed effect models, adjusted for potential confounders, were used to estimate the association between BALF HA concentration and the presence of AR on biopsy. The association between early posttransplant BALF HA levels and the development of CLAD was explored utilizing tertiles of maximum BALF HA level observed within the first 6 months of transplant.

resultsIn analyses adjusted for potential confounders, BALF HA concentration was significantly increased in association with AR (change in means on log-scale 0.31; 95% CI, 0.01-0.60;

conclusionsThese results demonstrate accumulation of HA in clinical AR and suggest a mechanism by which innate and adaptive immune activation might interact in the development of AR and CLAD.

Identifiers

PMID34549083
PMCPMC8440013
OpenAlexW3138667983

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.