Evidence map›Paper›PMID 34549044›Full record

ArticleERJ open research2021

Utility of fractional exhaled nitric oxide suppression as a prediction tool for progression to biologic therapy.

Claire A Butler, Alan J McMichael, Kirsty Honeyford, Louise Wright, Jayne Logan, Joshua Holmes, John Busby, Catherine E Hanratty, Freda Yang, Steven J Smith and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Measuring adherence to therapy in airways disease.Breathe (Sheffield, England) · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Claire A ButlerBelfast City Hospital, Belfast, UK.
Alan J McMichaelQueen's University Belfast, Belfast, UK.
Kirsty HoneyfordBelfast City Hospital, Belfast, UK.
Louise WrightBelfast City Hospital, Belfast, UK.
Jayne LoganBelfast City Hospital, Belfast, UK.
Joshua HolmesQueen's University Belfast, Belfast, UK.
John BusbyQueen's University Belfast, Belfast, UK.
Catherine E HanrattyBelfast City Hospital, Belfast, UK.
Freda YangGartnavel General Hospital and University of Glasgow, Glasgow, UK.
Steven J SmithGartnavel General Hospital and University of Glasgow, Glasgow, UK.
Kirsty MurrayGartnavel General Hospital and University of Glasgow, Glasgow, UK.
Rekha ChaudhuriGartnavel General Hospital and University of Glasgow, Glasgow, UK.
Liam G HeaneyBelfast City Hospital, Belfast, UK.
Belfast City Hospital · GBQueen's University Belfast · GBUniversity of Glasgow · GBGartnavel General Hospital · GBUniversity of Ulster · GB

Funding

Medical Research Council MR/M016579/1
6 · The paper itself

Abstract

rationaleThe utility of fractional exhaled nitric oxide (

objectivesWe examined the utility of FeNOSuppT in prediction of progression to biologic agents or discharge from specialist care.

methodsFeNOSuppT was measured at home using remote monitoring technology of inhaler use alongside daily MEASUREMENTS AND MAIN

resultsOf the 162 subjects, 135 successfully completed the test with 81 (60%) positive

conclusionsA negative FeNOSuppT correlates with progression to biologic therapy. A positive FeNOSuppT, with subsequent maintenance of "optimised"

Identifiers

PMID34549044
PMCPMC8450452
OpenAlexW3180269880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.