Evidence map›Paper›PMID 34548873›Full record

ReviewJournal of otology2021

Peripheral vestibular system: Age-related vestibular loss and associated deficits.

Jennifer Coto, Carmen L Alvarez, Ivette Cejas, Brett M Colbert, Bonnie E Levin, Joshua Huppert, Tatjana Rundek, Carey Balaban, Susan H Blanton, David J Lee and 3 more

Abstract readReview
In one paragraph

Review in Journal of otology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. The necessity of motoric engagement in enhancing route memory.British journal of psychology (London, England : 1953) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer CotoUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.
Carmen L AlvarezSan Juan Bautista Medical School, Caguas, PR, USA.
Ivette CejasUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.
Brett M ColbertUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.
Bonnie E LevinUniversity of Miami Miller School of Medicine, Department of Neurology and the Evelyn F. McKnight Brain Institute, Miami, FL, USA.
Joshua HuppertUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.
Tatjana RundekUniversity of Miami Miller School of Medicine, Department of Neurology and the Evelyn F. McKnight Brain Institute, Miami, FL, USA.
Carey BalabanUniversity of Pittsburgh, Departments of Otolaryngology, Neurobiology, Communication Sciences & Disorders, and Bioengineering, Pittsburgh, PA, USA.
Susan H BlantonUniversity of Miami Miller School of Medicine, Dr. John T. Macdonald Department of Human Genetics, Miami, FL, USA.
David J LeeUniversity of Miami Miller School of Medicine, Department of Public Health Sciences, Miami, FL, USA.
David LoewensteinUniversity of Miami Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, Miami, FL, USA.
Michael HofferUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.
Xue Zhong LiuUniversity of Miami Miller School of Medicine, Department of Otolaryngology, Miami, FL, USA.

Funding

Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
NCATS NIH HHS KL2 TR002737
6 · The paper itself

Abstract

Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision, cognition), it is important to examine the individual contributions of these factors with ARVL. While the relationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015), little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system as an opportunity for examining brain function beyond balance, and into other areas, such as cognition and psychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide the development of integrated interventions for patients who remain at risk for decline. In this review, we will discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relates to neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, with an emphasis on improving care for patients with ARVL.

Indexed as

Age-related vestibular lossBalanceCognitivePeripheral vestibular systemPsychologicalVision

Identifiers

PMID34548873
PMCPMC8438634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.