Evidence map›Paper›PMID 34548789›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System.

Roberta Pisi, Marina Aiello, Annalisa Frizzelli, Luigino Calzetta, Laura Marchi, Giuseppina Bertorelli, Giovanna Pisi, Alfredo Chetta

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Respiratory oscillometry in monitoring lung transplant allograft function: a systematic scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
  7. Article
  8. Article
  9. Understanding Small Airway Dysfunction in Tobacco-Exposed Adults Using Oscillometry.American journal of respiratory and critical care medicine · 2025
    Article
  10. Article
  11. Article
  12. Diagnostic Potential of Oscillometry: A Population-based Approach.American journal of respiratory and critical care medicine · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Roberta PisiDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.ORCID 0000-0001-5552-2912
Marina AielloDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.ORCID 0000-0003-0636-5345
Annalisa FrizzelliDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.
Luigino CalzettaDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.ORCID 0000-0003-0456-069X
Laura MarchiDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.
Giuseppina BertorelliDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.
Giovanna PisiDepartment of Pediatrics, Cystic Fibrosis Center, University Hospital, Parma, Italy.
Alfredo ChettaDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.ORCID 0000-0002-0416-5334
University of Parma · ITCystic Fibrosis Research Foundation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSmoking-induced bronchiolitis with progressive small airway dysfunction (SAD) is a leading cause of chronic obstructive pulmonary disease. We investigated the value of using the impulse oscillometry system (IOS) to detect SAD in asymptomatic smokers with preserved spirometry. PATIENTS AND

methodsWe included 75 asymptomatic smokers (37 females, mean age 47±12 years, 26±17 pack/year) with preserved spirometry [forced expiratory volume at 1st second (FEV1)/forced vital capacity (FVC) ≥0.70 and normal FVC] and 34 never-smokers (19 females, mean age 42±15 years).

resultsIn smokers, pack/years were significantly related to spirometry and IOS parameters (p < 0.05). The values of the fall in resistance from 5 Hz to 20 Hz (R5 - R20) were significantly and inversely related to the values of the ratio of forced expiratory volume in 3 and in 6 seconds (FEV

conclusionThis study demonstrates that IOS has the potential to detect SAD in asymptomatic heavy smokers with preserved spirometry and with FEV3/FEV6 values in the normal range. We confirm that IOS provides parameters which can complement traditional measurements of pulmonary function.

Indexed as

Pulmonary Disease, Chronic ObstructiveSmokersAdultFemaleForced Expiratory VolumeHumansLungMiddle AgedOscillometrySpirometryCOPDimpulse oscillometry systemsmall airway dysfunctionsmokersspirometry

Identifiers

PMID34548789
PMCPMC8449545
OpenAlexW3200747780

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.